MicroRNAs (miRNAs) are small non-coding RNAs that can regulate their target genes at the post-transcriptional level. Skeletal muscle comprises different fiber types that can be broadly classified as red, intermediate, and white. Recently, a set of miRNAs was found expressed in a fiber type-specific manner in red and white fiber types. However, an in-depth analysis of the miRNA transcriptome diff...

The overexpression of tissue factor (TF) observed in numerous cancer cells and clinical samples of human cancers make TF an ideal target for cancer therapy. Here, we report an energized fusion protein, hlFVII-LDP-AE, which can be used for cancer therapy and is composed of a human Factor VII light chain (hlFVII) conjugated to the cytotoxic antibiotic lidamycin (LDM, LDP-AE). hlFVII-LDP-AE binds ...

Predation affects life history traits of nearly all organisms and the population consequences of predator avoidance are often larger than predation itself. Climate change has been shown to cause phenological changes. These changes are not necessarily similar between species and may cause mismatches between prey and predator. Eurasian sparrowhawk Accipiter nisus, the main predator of passerines,...

properties of laidlomycin, C37H62O12(M+; 698), m.p. 151-153°, [a] "]2,2 +51.3°(CHC13), obtained from culture filtrates of a strain of Streptomyces eurocidicus var. asterocidicus were previously reported by us.') Chemical structure of this antibiotic had not been elucidated at that time. The present communication deals with this issue, and structure I (Fig. 4), is proposed on the basis of the fo...

The aim of our study was to investigate fiber type distribution and contractile characteristics of Latissimus Dorsi muscle (LDM). Samples were collected from 18 young healthy subjects (9 males and 9 females) through percutaneous fine needle muscle biopsy. The results showed a predominance of fast myosin heavy chain isoforms (MyHC) with 42% of MyHC 2A and 25% of MyHC 2X, while MyHC 1 represented...

CHANGES IN CEREBRAL WHITE MATTER, VASCULAR RISK ANDCOGNITION ACROSS THE ADULT LIFESPANbyANDREW R. BENDERMay 2014Advisor: Dr. Naftali RazMajor: Psychology (Behavioral and Cognitive Neuroscience)Degree: Doctor of PhilosophyNumerous studies over the past decade have used diffusion tensor imaging (DTI) toexamine the associations between age, diffusion and ani...

Mathematical descriptions of classical particle size distribution (PSD) data are often used to estimate soil hydraulic properties. Laser diffraction methods (LDM) now provide more detailed PSD measurements, but deriving a function to characterize the entire range of particle sizes is a major challenge. The aim of this study was to compare the performance of eighteen PSD functions for fitting LD...

The development of (semi)-autonomous vehicles and communication between vehicles and infrastructure (V2X) will aid to improve road safety by identifying dangerous traffic scenes. A key to this is the Local Dynamic Map (LDM), which acts as an integration platform for static, semi-static, and dynamic information about traffic in a geographical context. At present, the LDM approach is purely datab...

Dim and small target detection in complex background is considered a difficult and challenging problem. Conventional algorithms using the local difference/mutation possibly produce high missed or mistaken detection rates. In this paper, we propose an effective algorithm for detecting dim and small infrared targets. In order to synchronously enhance targets and suppress complex background clutte...

Colon cancer is the third most common cancer in the world. The overexpression of tissue factor (TF) in colon cancer cells makes it an ideal target for colon cancer therapy. The purpose of the present study was to develop a TF-targeting energized fusion protein, mlFVII-LDP-AE, which is composed of a mouse Factor VII light chain (mlFVII) as the targeting domain conjugated to the highly cytotoxic ...