The Yersinia low-Ca^* response (LCR) is a reguiatory response in which a set of plasmid-borne operons is transcriptionaiiy regulated at 37 C in response to the presence or absence of mM concentrations of Ca^ .̂ LCR-reguiated operons encode secreted proteins with reguiatory and viruience roies as well as nonsecreted reguiatory proteins and components of the secretion machinery. Downregulation by ...

Chromatin loops juxtapose distal enhancers with active promoters, but their molecular architecture and relationship with transcription remain unclear. In erythroid cells, the locus control region (LCR) and β-globin promoter form a chromatin loop that requires transcription factor GATA1 and the associated molecule Ldb1. We employed artificial zinc fingers (ZF) to tether Ldb1 to the β-globin prom...

objective: β-thalassemia is caused by absence or reduction of β-globin chain synthesis. one of the effective therapeutic methods for this disease can be gene therapy by viral vectors. the capacity of lentiviral vectors is approximately 8 kb, we designed a 6 kb construct containing mini lcr and β-globin gene instead of lcr region. the aim of this study is to make a recombinant lentiviruses conta...

The second order statistics such as level crossing rate (LCR) and average outage duration (AOD) for switch and stay combining (SSC) receiver are analyzed in this paper. The presence of Hoyt fading at the branch's inputs is observed. The obtained expressions are calculated and shown graphically for different fading parameters and values of threshold decision. Key-Words: Average outage duration (...

Optical burst switching (OBS) has been proposed as a competitive hybrid switching technology to support the nextgeneration optical Internet. This paper addresses the problem of contention in OBS networks and introduces a new contention resolution algorithm called Look-ahead window Contention Resolution (LCR) that can also support service differentiation. Simulation results show that the perform...

The post-crisis liquidity framework improves banking stability by imposing stricter requirements. However, consistent bank performance continues to be an essential factor in achieving this goal. This study examines the impact of coverage ratio (LCR) on profitability and non-performing assets (NPAs) Indian banks using annual data from 2010 2019. By applying dynamic panel regression technique, we...

Intracellular Local Ca releases (LCRs) from sarcoplasmic reticulum (SR) regulate cardiac pacemaker cell function by activation of electrogenic Na/Ca exchanger (NCX) during diastole. Prior studies demonstrated the existence of powerful compensatory mechanisms of LCR regulation via a complex local cross-talk of Ca pump, release and NCX. One major obstacle to study these mechanisms is that LCR exh...

Local Ca2+ Releases (LCRs) are crucial events involved in cardiac pacemaker cell function. However, specific algorithms for automatic LCR detection and analysis have not been developed in live, spontaneously beating pacemaker cells. In the present study we measured LCRs using a high-speed 2D-camera in spontaneously contracting sinoatrial (SA) node cells isolated from rabbit and guinea pig and d...