PURPOSE Results from longitudinal studies about the association between physical activity and chronic obstructive pulmonary disease (COPD) may have been biased because they did not properly adjust for time-dependent confounders. Marginal structural models (MSMs) have been proposed to address this type of confounding. We sought to assess the presence of time-dependent confounding in the associat...

Standard statistical analyses of observational data often exclude valuable information from individuals with incomplete measurements. This may lead to biased estimates of the treatment effect and loss of precision. The issue of missing data for inverse probability of treatment weighted estimation of marginal structural models (MSMs) has often been addressed, though little has been done to compa...

Differential proteomic analysis has arisen as a large-scale means to discern proteome-wide changes upon treatment, injury, or disease. Tandem protein separation methods are required for large-scale differential proteomic analysis. Here, a novel multidimensional platform for resolving and differentially analyzing complex biological samples is presented. The platform, collectively termed CAX-PAGE...

An overview is provided of recent developments in the use of latent class (LC) and other types of %nite mixture models for classi%cation purposes. Several extensions of existing models are presented. Two basic types of LC models for classi%cation are de%ned: supervised and unsupervised structures. Their most important special cases are presented and illustrated with an empirical example. c © 20...

Along with the creation of new maps, current efforts for improving global land cover (GLC) maps focus on integrating maps by accounting for their relative merits, e.g., agreement amongst maps or map accuracy. Such integration efforts may benefit from the use of multiple GLC reference datasets. Using available reference datasets, this study assesses spatial accuracy of recent GLC maps and compar...

In this month’s “Column Watch,” Ron Majors discusses advances in multidimensional chromatography and comprehensive multidimensional chromatography. These techniques are well suited for the separation of complex samples. Although GC GC is fairly well developed, LC LC is in its infancy. But with fast LC columns, based on monoliths, superficially porous particles, and short sub-2m particle columns...

abstract background: “polycystic ovary syndrome (pcos) is a complex endocrine and metabolic disorder associated with ovulatory dysfunction”. “autonomic and central nervous systems play important roles in the regulation of ovarian physiology”. the noradrenergic nucleus locus coeruleus (lc) plays a central role in the regulation of the sympathetic nervous system and synaptically connected to the ...

Objective Chemotherapy may damage ovaries. L-carnitine (LC) as a type of flavonoid antioxidants and bone marrow stromal cells (BMSCs) as a type of mesenchymal stem cells may recover damaged ovaries. It seems that LC has favorable effects on differentiation, increasing lifespan and decreasing apoptosis in BMSCs. The aim of this study was to investigate the effects of co-administration of BMSCs a...