Variations in the N-methyl-d-aspartate receptor 2B subunit gene (GRIN2B) have been associated with schizophrenia, a psychiatric disorder associated with reduced left-hemispheric language dominance. Here, we investigated, whether different polymorphisms in GRIN2B influence language lateralization and handedness in healthy individuals. In a cohort of 424 genetically unrelated participants we foun...

A number of studies have reported changes in the hemispheric dominance in autism spectrum disorder (ASD) patients on functional, biochemical, and morphological level. Since asymmetry of the brain is also found in many vertebrates, we analyzed whether prenatal zinc deficient (PZD) mice, a mouse model with ASD like behavior, show alterations regarding brain lateralization on molecular and behavio...

Amphibians provide a unique opportunity for identifying possible links between lateralized behaviors, locomotion, and phylogeny and for addressing the origin of lateralized behaviors of higher vertebrates. Five anuran species with different locomotive habits were tested for forelimb and hind limb preferences during 2 stereotyped behavior sequences--wiping a foreign object off their snout and ri...

Hemispheric specialization for linguistic material was compared for normal and dyslexic subjects under dichotic listening (Experiment 1) and hemi-retinal presentation (Experiment 2) conditions. In both experiments, group data indicated that dyslexic subjects were, overall, less accurate in their performance than normals but that both groups showed similar right ear/visual field superiority. How...

This study examines the structural integrity and the hemispheric lateralization patterns of four major association fiber pathways in a group of French dyslexic children and age-matched controls (from 9 to 14 years), using high angular diffusion imaging combined with spherical deconvolution tractography. Compared with age-matched controls, dyslexic children show increased hindrance-modulated ori...

To investigate lateralization of duration and pitch discrimination processing with emphasis on the influences of task difficulty, we used event-related functional magnetic resonance imaging. Seventeen healthy volunteers performed paired auditory discrimination tasks at varying levels of difficulty. Analysis of lateralization effects revealed leftward lateralization within the insular and the te...

In this study the use of functional MRI (fMRI) for measuring language lateralization non-invasively was examined. The subjects were seven patients with histories of temporal lobe epilepsy who had undergone Wada testing for pre-surgical evaluation. Four patients were left-hemisphere-dominant and three were right-hemisphere-dominant for language. They received fMRI scans while they made semantic ...

OBJECTIVE To analyze the agreement rate of proton magnetic spectroscopy with magnetic resonance image (MRI) and surface electroencephalography (EEG) in extratemporal neocortical epilepsies. METHODS A cross-sectional study, type series of cases included 33 patients, age range 13-59 years old, of both gender, presenting structural alteration identified by MRI (75.8%) or by neurophysiologic tech...

Hip arthroscopy is commonly used both to diagnose and treat different underlying hip conditions. It may be performed either by a supine or lateral approach. A peroneal post is commonly used with a fracture table in both the supine and lateral positions to provide lateralization and traction of the femur. Adequate distraction of the hip joint may be difficult without the peroneal post. We achiev...

The sensation of pitch appears normally to arise from the operation of a multiplicity of mechanisms. It is not readily possible to distinguish their relative contributions and it would be an advantage to be able to study an effect which was dependent on the operation of only one type of mediation. The aim of the present experiments was to arrive at and to examine a situation in which only a neu...