I hypothesize that dormant bacterial genomes in the form of intracytoplasmic dense bodies are a mechanism for bacterial persistence, and may cause infections systematically overlooked in clinical medicine. Cell wall-defective bacteria may be involved in latent and chronic infection and may retain their pathogenicity. Persisting small, electron dense, elementary bodies derived from cell wall-def...

In this paper we present a model to estimate the density of aedes mosquitoes in a community affected by dengue. The method consists in fitting a continuous function to the incidence of dengue infections, from which the density of infected mosquitoes is derived straightforwardly. Further derivations allow the calculation of the latent and susceptible mosquitoes' densities, the sum of the three e...

Emerging Infectious Diseases • www.cdc.gov/eid • Vol. 13, No. 5, May 2007 791 dulating severity and relapsed after a latent period of another 2 weeks. Although the isolate was highly resistant to clarithromycin in vitro, the patient improved clinically as symptoms disappeared. Results of stool cultures taken 5 weeks after resolution of clinical symptoms were negative. The clinical course of thi...

In a prospective infant cohort, 21 infants developed Plasmodium vivax malaria during their first year. Twelve of their mothers also had vivax malaria in the corresponding pregnancies or postpartum period. The genotypes of the maternal and infant infections were all different. Eight of the 12 mothers and 9 of the 21 infants had recurrent infections. Relapse parasite genotypes were different to t...

We present a within-host model for tuberculosis (TB) infections, which directly models the bacterial load over the course of the infection. This allows for a future multi-scale model which can make use of the link between pathogen load and transmission potential of an infected host. By modelling the interactions between the host immune system, the invading bacteria and granulomas which are char...

background: the differentiation between acute and latent forms of the toxoplasma gondii ( t. gondii ) infection is still considered as a complicated issue. this study was aimed to elucidate the status of infection in the blood donors and the probable importance of blood transfusion in the transmission of the infection through detecting both immunological and genetic markers of acute and latent ...

The viral genetic elements that determine the in vivo reactivation efficiencies of fully replication competent wild-type herpes simplex virus (HSV) strains have not been identified. Among the common laboratory strains, KOS reactivates in vivo at a lower efficiency than either strain 17syn+ or strain McKrae. An important first step in understanding the molecular basis for this observation is to ...

OBJECTIVES To assess the prevalence of syphilis infections among men who have sex with men (MSM) accessing the Brisbane Sexual Health Clinic during the period 1997 up to May 2003, data were collated through three clinical programmes conducted by the service-a large inner city mainstream sexual health clinic and two small outreach sessional clinics conducted on the site of male sex on premises v...