Localized necrosis of the bone, cartilage, and soft tissue of the external auditory canal is an uncommon side effect of radiotherapy to the parotid region. Five patients developed late onset skin necrosis of a quadrant of the ear canal secondary to an underlying osteoradionecrosis of the tympanic ring. We report a one-stage procedure to excise the necrotic tissue and replace it with a local rot...

Lichen Planus (LP) is a chronic, inflammatory, autoimmune disease that affects the skin, oral mucosa, genital mucosa, scalp and nails. LP lesions are described using the six P's (planar [flat-topped], purple, polygonal, pruritic, papules and plaques). Onset is usually acute, affecting the flexor surfaces of the wrists, forearms, and legs. The lesions are often covered by lacy, reticular, white ...

The aim of the study was to examine for the first time the various aspects of canine atopic dermatitis (CAD) presenting in a Middle Eastern country. Medical records of 164 dogs diagnosed with CAD were evaluated. Associations between signalment, lifestyle, clinical signs and allergens were evaluated statistically. Labrador Retriever, German Shepherd dog, Boxer, French Bulldog, Golden Retriever a...

Methotrexate (MTX) is an antifolic drug used in the treatment of immune-mediated and neoplastic diseases. Initiation or dosage changes in MTX therapy can cause mucositis and bone marrow suppression. Skin lesions due to acute MTX toxicity are rare, but they serve as a herald for later-onset pancytopenia. Therefore, identification of those cutaneous lesions might help to initiate rescue strategie...

Pityriasis rubra pilaris (PRP) is a rare, chronic papulosquamous skin disorder. The skin lesions rarely have a predilection to sun-exposed areas although it is known that natural sunlight and phototherapy can exacerbate PRP [1–4]. We present a case of a patient suffering from pityriasis rubra pilaris with photoexposed distribution and photosensitivity exclusively to UVB objectively detected by ...

BACKGROUND Coronary sequelae that persist after Kawasaki disease (KD) have been associated with obstructive changes of the lesions and coronary vascular events in adolescents and young adults. However, little is known about the association between sequelae late after KD and inflammatory markers, which are potential mediators and markers for atherogenesis. METHODS AND RESULTS Cross-sectional s...

Abstract Background SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, and osteitis) is a rare, heterogeneous, self-limited disease of unknown etiology. It involves progressive bone joint damage, skin lesions may occur at different times in the course disease. Skin are characterized by neutrophil dermatosis. Its management empirical mainly symptomatic, nonsteroidal anti-inflammatory dru...