Patients with gastroesophageal reflux disease (GERD) display enhanced laryngeal reflex reactivity to stimuli that may be due to sensitization of the laryngeal C-fibers by acid and pepsin. Menthol, a ligand of transient receptor potential melastatin-8 (TRPM8), relieves throat irritation. However, the possibility that GERD induces laryngeal C-fiber hypersensitivity to cigarette smoke (CS) and tha...

BACKGROUND To compare surgical outcomes of thoracoscopic and laparoscopic esophagectomy with open esophagectomy in order to study the learning curve of minimally invasive surgery for esophageal cancers. METHODS Among 109 esophageal cancer patients retrospectively studied, 59 patients underwent minimally invasive esophagectomy (MIE) and 50 underwent open surgery (OE). In the MIE group, the fir...

a 22-year-old man presented with exertional dyspnea commencing one month prior to his admission. echocardiography revealed a non-homogenous mass, and the pathology examination of the pericardial biopsy was compatible with angiosarcoma.

OBJECTIVES/HYPOTHESIS To define normative amplitude and latency of vagus, recurrent laryngeal nerve (RLN), and external branch of superior laryngeal nerve (EBSLN) and to apply them to postoperative neural function documentation. To our knowledge, this is the first study to report electrophysiologic characteristics of all three nerves in a consecutive patient series. STUDY DESIGN Prospective. ...

OBJECTIVES/HYPOTHESIS Evaluate the effects of asymmetric superior laryngeal nerve stimulation on the vibratory phase, laryngeal posture, and acoustics. STUDY DESIGN Basic science study using an in vivo canine model. METHODS The superior laryngeal nerves were symmetrically and asymmetrically stimulated over eight activation levels to mimic laryngeal asymmetries representing various levels of...

Phoniatric Aspects of Laryngeal Disorders Hajime Hirose, M. D. Research Institute of Logopedics and Phoniatrics, Faculty of Medicine, University of Tokyo The disorder of voice is one of the most common problems of laryngeal pathologies. In the present report, phoniatric profiles of typical laryngeal disorders were presented and the relationship between the characteristics of abnormal voice and ...

BACKGROUND The impact of recurrent laryngeal nerve (RLN) injury management in thyroid surgery seems to be relevant to patients, National Healthcare System (NHS), and society. METHODS We studied resource consumption in the management of patients with RLN injury versus noninjured patients investigating 3 perspectives (patients, NHS, and society) in 5 clinical pathways. RESULTS Direct medical ...

MicroRNAs (miRs, miRs) is a class of small non-coding RNAs, which posttranscriptionally regulate gene expression. Deregulated miRs are frequently obseved in patients with laryngeal cancer. In addition, numerous studies have showed miRs play significant roles in the pathogenesis of laryngeal cancer through regulating tumor cell proliferation, metastasis, invasion and apoptosis. miR can play eith...

Objective: Minimal Invasive Esophagectomy (MIE) has become the main radical treatment for esophageal cancer. However, there are still many controversies on MIE. This paper compared the shortterm therapeutic efficacy between minimally invasive Ivor-Lewis esophagectomy and McKeown esophagectomy for esophageal cancer. Methods: The clinical data of patients with esophageal cancer treated by MIE fro...

treacher collin’s syndrome (tcs) is a rare inherited condition characterized by bilateral and symmetric abnormalities of structures within the first and second bronchial arches. patients with tcs present a serious problem to anesthetists maintaining their airway as upper airway obstruction and difficult tracheal intubation due to severe facial deformity. because of retrognathia, airway manageme...