The first line of treatment for active acromegaly is still neurosurgery followed by radiotherapy. Octreotide (1), slow-release (SR) lanreotide (2) and octreotide LAR (3) are currently administered before surgery or in patients in whom surgery and/or radiotherapy have failed to restore normal growth hormone (GH)/insulin-like growth factor-I (IGF-I) levels. Cozzi et al. (4) have recently shown th...

Methods A prospective 10-year-follow-up study has been designed to evaluate 194 LAR patients and 97 healthy controls. All LAR patients had positive response to nasal allergen provocation test (NAPT) with at least one aeroallergen. Demographic and clinical questionnaire, spirometry, skin prick testing, and serum specific IgE antibodies to common aeroallergens were evaluated yearly, and NAPT were...

Background Local allergic rhinitis (LAR) is characterized by negative skin testing and serum specific IgE. Diagnosis is based on nasal provocation test (NPT), very sensitive but time-consuming, and/or presence of local synthesis of specific IgE (sIgE) which shows low sensitivity (22%). The aim of the study was to evaluate the presence of specific D. pteronyssinus (DP) activation of basophils by...

brown trout, salmo trutta fario, has a wide range of distribution in the north of iran and in karaj, lighvanchai and karun rivers, but there is no report about its feeding behavior in some water resources including the lar natural park. in order to study feeding behavior of this fish during spawning season, a survey was carried out in the rivers of elarm, aab-sefid, kamardasht and delichayi in ...

GRIP is present at excitatory synapses by immunocyto-Technology chemistry, but GRIP also exists abundantly in nonsynap-Taejon 305-701 tic locations such as in dendritic shafts (where it is asso-Korea ciated with vesicles and microtubules), axons, axon 4 Department of Cell Biology and Anatomy terminals, and cell soma (associated with endoplasmic Summary example, the association of GRIP with intr...

Introduction: Due to the relatively low closure temperature of feldspar, Ar-Ar ages of shocked meteorites typically record the age of an impact, not the formation age. Ar-Ar dating of lunar rocks has shown an increase in the impact rate around 3.9Ga [1], and many eucrites [2] and H chondrites [3] give similar ages, but with a larger spread than in the lunar case. Although only a small number of...

In this report we summarize the recent paper [Taylor et al., 2014] which proposes new inference tools for methods that perform variable selection and estimation in an adaptive regression. Although this paper mainly studies forward stepwise regression (FS) and least angle regression (LAR), the approach in this paper is not limited to these cases. This paper describes how to carry out exact infer...

We present a case of metastatic recurrence of carcinoid tumor accompanied by carcinoid syndrome in a 68-year-old Japanese man, 12 years after resection of typical pulmonary carcinoid. Histopathologic examination from percutaneous liver biopsy revealed metastatic typical carcinoid. Clinical symptoms gradually improved after administration of octreotide LAR. Two years after starting treatment, th...

Two papers in this issue of Neuron add a new dimension to our understanding of liprin and LAR RPTP function during synapse formation. present evidence that Dliprin-alpha interacts with Dlar to regulate presynaptic morphogenesis of the Drosophila neuromuscular junction. demonstrate that mammalian liprin-alpha1 forms a complex with the PDZ protein GRIP and LAR in both pre- and postsynaptic compar...