Toxic epidermal necrolysis and Stevens-Johnson syndrome are rare, life treating cutaneous reactions. Most cases of toxic epidermal necrolysis are drug induced. The drugs with the highest estimated incidence include co-trimoxazloe (trimethoprim-sulfamethoxazole), sulfadoxine-pyrethamine, and carbamazepine. Among other drugs, the reported reaction rates are relatively low for lamotrigine and sulb...

Lamotrigine is a mood-stabilizing drug used in maintenance treatment of bipolar I disease. There are adverse effects with lamotrigine such as a headache, blurred vision, diplopia, somnolence, ataxia, dizziness, rash, Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis. SJS is a life-threatening, blistering mucocutaneous disease. SJS is characterized by the presence of flat, diffuse e...

• Four anti-epileptic drugs (AEDs) have been approved for the adjunctive treatment of primary generalized tonic-clonic seizures (PGTCS) in adults: topiramate [TPM], lamotrigine [LTG]/ lamotrigine-XR [LTG-XR], levetiracetam [LEV], and perampanel [PER]. • Five randomized-controlled trials were conducted to support these approvals [1-5]. Lamotrigine-XR applies to the US but not the EU. • These tri...

263 V – ‘appetite and weight change’, VI – ‘anxiety’ and VII – ‘anergia’. A signifi cant therapeutic effect of lamotrigine in bipolar depression was found using the ‘depressive cognitions’ factor (from week 3) and ‘psychomotor retardation’ (from week 4). Conclusions: This study has identifi ed seven factors of the HDRS in a large sample of patients with bipolar depression. It suggests that the ...

A reversed-phase high-performance liquid chromatography assay was developed and validated to determine plasma and brain lamotrigine concentrations allowing pharmacokinetic-pharmacodynamic studies of this new antiepileptic drug in patients and laboratory animals. Lamotrigine and its internal standard were extracted, under alkaline conditions, from plasma and brain homogenate, into ethyl acetate;...