................................................................................................ 5 ACKNOWLEDGEMENTS .......................................................................... 7 CONTENTS ................................................................................................ 9 LIST OF ORIGINAL PUBLICATIONS ..................................................... 12 ABBREVIAT...

Compared with some other species, insulin dysregulation in equids is poorly understood. However, hyperinsulinemia causes laminitis, a significant and often lethal disease affecting the pedal bone/hoof wall attachment site. Until recently, hyperinsulinemia has been considered a counterregulatory response to insulin resistance (IR), but there is growing evidence to support a gastrointestinal etio...