Utilizing a pH-stat method, the rates of mucosal and serosal alkalinization were measured separately in the seawater eel intestine. These two rates were dependent on contralateral HCO3" concentration and were inhibited by contralateral application of DIDS, an inhibitor of HCO3~ transport, indicating that the mucosal and serosal alkalinization are due to HCO3~ secretion and absorption, respectiv...

INTRODUCTION The objective of the study is to determine the level of agreement between measured total carbon dioxide (TCO2) and calculated bicarbonate (HCO3-) in our laboratory. MATERIALS AND METHODS TCO2 and HCO3- values of 1820 samples drawn at the same time from the patient were compared. TCO2 from venous samples was measured on Dimension RxL while HCO3- was obtained from arterial blood ga...

One of the major tasks of the renal proximal tubule is to secrete acid into the tubule lumen, thereby reabsorbing approximately 80% of the filtered HCO3- as well as generating new HCO3- for regulating blood pH. This review summarizes the cellular and molecular events that underlie four major processes in HCO3- reabsorption. The first is CO2 entry across the apical membrane, which in large part ...

1. Aedes dorsalis larvae are one of the few organisms capable of inhabiting hypersaline NaHCO3-CO3 lakes. Under laboratory conditions larvae can survive and develop normally in saline media with pH values of 10-5, HCO3~ concentrations of 250 mM, or CO3 ~ concentrations of 100 mM. 2. Despite ingestion of alkaline media at a rate equal to 130% of larval body wt/day, these insects regulated haemol...

Several studies suggest the involvement of Na+ and HCO3- transport in the formation of cerebrospinal fluid. Two Na+-dependent HCO3- transporters were recently localized to the epithelial cells of the rat choroid plexus (NBCn1 and NCBE), and the mRNA for a third protein was also detected (NBCe2) (Praetorius J, Nejsum LN, and Nielsen S. Am J Physiol Cell Physiol 286: C601-C610, 2004). Our goal wa...

The distribution of Na(+)-independent Cl(-)-HCO3- exchange was studied in individual intercalated cells from in vitro perfused rabbit outer CCDs using dual excitation laser scanning confocal microscopy by measuring the pHi response to sequential removal of Cl- from both sides of the tubule. Three patterns of intracellular pH (pHi) response were observed. 39% of intercalated cells had only apica...

In this paper we demonstrate, for the first time, the feasibility of a new imaging concept - combined hyperpolarized (13)C-pyruvate magnetic resonance spectroscopic imaging (MRSI) and (18)F-FDG-PET imaging. This procedure was performed in a clinical PET/MRI scanner with a canine cancer patient. We have named this concept hyper PET. Intravenous injection of the hyperpolarized (13)C-pyruvate resu...

Abstract The hydrogeochemical analysis and numerical simulation were conducted to explore the impact of land reclamation on submarine groundwater discharge evolution in seawater intrusion-retreat processes eastern Jiangsu, China. results indicated that origin salt most is saltwater mixing, weathering-dissolution minerals enriches fresh groundwater. path coastal Jiangsu Ca-Na-HCO3-Cl ? Ca-Na-Cl-...

[1] While much of the dissolved organic carbon (DOC) within rivers is destined for mineralization to CO2, a substantial fraction of riverine bicarbonate (HCO3 ) flux represents a CO2 sink, as a result of weathering processes that sequester CO2 as HCO3 . We explored landscape-level controls on DOC and HCO3 flux in subcatchments of the boreal, with a specific focus on the effect of permafrost on ...