Although protein ubiquitination has been shown to regulate multiple processes during host response to Salmonella enterica serovar Typhimurium infection, specific functions of host deubiquitinating enzymes remain unknown in this bacterial infection. By using chemical proteomics approach, in which deubiquitinating enzymes were labeled by an active-site probe and analyzed by quantitative proteomic...

BACKGROUND Although the measurement site at L4-L5 for visceral adipose tissue (VAT) has been commonly accepted, some researchers suggest that additional upper sites (i.e., L1-L2 and L2-L3) are useful for estimating VAT volume. Therefore, determining the optimum measurement site remains challenging and has become important in determining VAT volume. We investigated the influence of a single-slic...

Object: Previous reports have indicated that the level of lumbar spinal canal stenosis (LSCS) often differs from that diagnosed from neurological symptoms, and L5 nerve roots are often affected by stenosis at the L2–L3 or L3–L4 level; however, few cases have been described. Decompression surgery for upper lumbar spinal canal stenosis (LSCS) of L2–L3 and L3–L4 causing L5 and S1 symptoms was inve...

BACKGROUND The association of lumbar spine instability between laminectomy and laminotomy has been clinically studied, but the corresponding in vitro biomechanical studies have not been reported. We investigated the hypothesis that the integrity of the posterior complex (spinous process-interspinous ligament-spinous process) plays an important role on the postoperative spinal stability in decom...

Study Design Systematic review. Study Rationale Adult scoliosis is a common disorder that is associated with significantly higher pain, functional impairment, and effect on quality of life than those without scoliosis. Surgical spinal fusion has led to quantifiable improvement in patient's quality of life. However, for patients undergoing long lumbar fusion, the decision to stop the fusion at L...

BACKGROUND The purpose of this biomechanical in vitro study was to compare the kinematics and intradiscal pressure achieved with 2 methods: L4-L5 pedicle screw-rod fixation (PSRF) with an upper L3-L4 Coflex device and L4-L5 PSRF alone. The results were used to characterize the biomechanics of the topping-off operation with a Coflex device for the lumbar motion segment adjacent to single-level r...

PURPOSE The authors investigated the effect of lumbar facet tropism (FT) on intervertebral disc degeneration (DD), facet joint degeneration (FJD), and segmental translational motion. MATERIALS AND METHODS Using kinetic MRI (KMRI), lumbar FT, which was defined as a difference in symmetry of more than 7 degrees between the orientations of the facet joints, was investigated in 900 functional spi...

Lumbar spinal canal stenosis (LSS) is diagnosed based on physical examination and radiological documentation of lumbar spinal canal narrowing. Differential diagnosis of the level of lumbar radiculopathy is difficult in multilevel spinal stenosis. Therefore, the authors focused on gait analysis as a classification method to improve diagnostic accuracy. The goal of this study was to identify gait...

In the management of a pelvic fracture prompt recognition of an unstable fracture pattern is important in reducing mortality and morbidity. It is believed that a fracture of the transverse process of L5 is a predictor of pelvic fracture instability. However, there is little evidence in the literature to support this view. The aim of this study was to determine whether a fracture of the transver...