The bioactivity of nitric oxide (.NO) depends, in part, on its interaction with superoxide. Usually, superoxide dismutase (SOD) preserves .NO bioactivity by limiting the availability of superoxide. Ascorbic acid also effectively scavenges superoxide, but the extent to which this interaction is necessary for intact .NO bioactivity is not known. Therefore, the present study examined the effect of...

required for the prevention of deficiency diseases such as scurvy, it also might be useful for reducing the risk of developing chronic diseases such as cancer, cardiovascular disorders, and cataracts. The protective mechanism probably is due to the antioxidant effect of ascorbic acid (10). Therefore, applications of various detection systems and analytical procedures for the separation of ascor...

Evidence that glucose1 is the ultimate g-carbon precursor of ascorbic acid in the rat was first obtained by Jackel, Mosbach, Burns, and King (1). They administered uniformly labeled glucose-C** to Chloretone-treated rats and recovered uniformly labeled ascorbic acid from the urine. Subsequently, Horowitz, Doerschuk, and King (2) and Burns and Mosbach (3) discovered that when glucose-l-C14 was a...

1) The effect of 1 g daily doses of L-ascorbic acid in reducing the incidence of the common cold in a group of volunteers was compared with a control group receiving a placebo, The survey lasted 16 weeks during the winter months of 1971/1972. The results (1) showed that the 47 volunteers receiving L-ascorbic acid suffered a total of 44 colds, whereas the 43 people taking dummy pills had 80 cold...

Evidence that glucose1 is the ultimate g-carbon precursor of ascorbic acid in the rat was first obtained by Jackel, Mosbach, Burns, and King (1). They administered uniformly labeled glucose-C** to Chloretone-treated rats and recovered uniformly labeled ascorbic acid from the urine. Subsequently, Horowitz, Doerschuk, and King (2) and Burns and Mosbach (3) discovered that when glucose-l-C14 was a...

Using a gas-chromatographic method, we examined the effects of phosphate concentration, added calcium chloride, and pH on precipitation of oxalate from urine. All three factors are important, but the pH of precipitation is particularly so, especially in the presence of even normal concentrations of ascorbic acid. At pH 8, increases in measured oxalate ranged from 20% at an ascorbic acid concent...

BACKGROUND The aim of this study was to assess the effect of diet supplementation with L-ascorbic acid (500 mg/L), tocopherol (3 mg/kg b.w.), and/or a water soluble analog of tocopherol (Trolox) (48 mg/L) on ion transport in the colon of rats subjected to a chronic exposure (9 months) to 0.1% lead acetate in drinking water. MATERIAL/METHODS The electrophysiological parameters of the colon wal...