نتایج جستجو برای: kinase

تعداد نتایج: 227329  

Journal: :Revista Brasileira de Farmacognosia 2022

Abstract Doxorubicin, sold under the brand name Adriamycin among others, is an important drug for cancer therapy; however, its use limited by cardiotoxicity. Ginsenoside Rg2 extracted from Panax ginseng C.A.Mey., Araliaceae, which believed to have cardioprotective properties. However, date, there been no reports on whether ginsenoside could protect cardiomyocytes against doxorubicin. In this st...

Journal: :Indian Journal of Pharmaceutical Sciences 2022

Chronic rhinosinusitis is a chronic inflammatory condition that caused by many factors. However, the underlying mechanism of remains unclear. The current study focused on roles triptolide hydrogen peroxide treated nasal epithelial cells and underling mechanism. Hydrogen human were cultured different concentrations triptolide, cell growth death determined counting kit-8 flow cytometry methods. M...

Journal: :Chemistry 2021

Quinoline-3-carboxamides are an essential class of drug-like small molecules that known to inhibit the phosphatidylinositol 3-kinase-related kinases (PIKK) family kinases. The quinoline nitrogen is shown bind hinge region kinases, making them competitive inhibitors adenosine triphosphate (ATP). We have previously designed and synthesized quinoline-3-carboxamides as potential ataxia telangiectas...

Journal: :npj precision oncology 2021

Abstract Glucocorticoids, such as dexamethasone and prednisolone, are widely used in cancer treatment. Different hematological malignancies respond differently to this treatment which, could be expected, correlates with outcome. In study, we have a glucocorticoid-induced gene signature develop deep learning model that can predict sensitivity. By combining expression data from cell lines patient...

Journal: :iranian journal of public health 0
zhi-ze chen

background: osteosarcoma is a malignant tumor with high mortality but effective therapy has not yet been developed. berberine, an isoquinoline alkaloid component in several chinese herbs including huanglian, has been shown to induce growth inhibition and the apoptosis of certain cancer cells. the aim of this study was to determine the role of berberine on human osteosarcoma cell lines u2os and ...

Journal: :Indian Journal of Pharmaceutical Sciences 2023

One of the leading causes diabetes-related deaths is myocardial damage, which may be cause heart failure in people with type 2 diabetes mellitus. The objective research was to look at impact coronary kind a pair This project aimed explore protective oleanolic acid on damage mellitus and investigate connected mechanism. Specific pathogen free grade db/db male mice were elected as model, while Db...

Journal: :iranian biomedical journal 0
محمود اوراضی زاده mahmoud orazizadeh ایران رشیدی iran rashidi جمیله صارمی jamileh saremi محمود لطیفی mahmoud latifi

background: endometrial remodeling occurs during each menstrual cycle in women. reports have shown that, in a variety of cell types, processes such as proliferation, signaling complex formation and extra cellular matrix remodeling require a cytoplasmic tyrosine kinase, focal adhesion kinase (fak). the present study has focused on the expression pattern of fak in human endometrium during the men...

Journal: :journal of research in medical sciences 0
parvin mahzouni associate professor, department of pathology, school of medicine, isfahan university of medical sciences, isfahan, iran mohsen jafari resident, department of pathology, school of medicine, isfahan university of medical sciences, isfahan, iran

background : cd117 is a thyrosin kinase receptor encoded by c-kit proto-oncogene. it is expressed during normal development in some tissues and also in a subset of neoplasia especially gastrointestinal stromal tumors   (gists). treatment with thyrosin kinase inhibitors (e.g., imatinib) is useful in cd117- positive gists. the goal of this study is to investigate the expression of cd117 in glial ...

Journal: :Journal of Biological Chemistry 1960

Journal: :Future Journal of Pharmaceutical Sciences 2022

Abstract Background Caffeine, an alkaloid agent, has been globally used regularly in drinks, for the reduction skin cancers and wrinkle formation. As a result of previous, attempts have carried out to use caffeine cosmetology due its antioxidant UV ray protection effects. Our aim was evaluate effect on collagen resynthesis via proline prolidase biosynthesis mice, orally topically as mesoporous ...

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