OBJECTIVE To determine the type of malignant renal tumours subjected to radical nephrectomy at a tertiary care urology unit using the 2004 WHO classification for renal tumours. METHODS It was an observational study conducted at Department of Urology, AFIU Rawalpindi, from October 2008 to September 2010. The study included 92 patients with malignant renal tumours of both genders aged above 15 ...

In three experiments, chloroform was administered to mice by gavage in a toothpaste base or in arachis oil, in doses up to 60 mg/kg/d on 6 days/wk for 8 wks. Control groups were left untreated or given vehicle only. In general, there were more survivors in chloroform-treated groups than in the controls. In the case of the males of three strains (C57BL, CBA and CF/1), treatment was associated wi...

BACKGROUND A remarkable number of patients presents with multiple primary malignancies (MPM) over their lifetimes. In most cases inherited syndromes, iatrogenic, or viral factors are implicated, while in some cases it is not possible to ascertain a clear aetiopathogenesis. METHODS Starting from a series of 315 patients with MPM, we focused our attention on those with extremely infrequent comb...

BACKGROUND Parathyroid hormone (PTH) is a crucial regulator of calcium homoeostasis in humans. Although it is well known that PTH acts primarily on kidney and bone, the precise cellular and subcellular sites of PTH action have not been visualised in human tissues. METHOD We developed and characterised a novel anti-peptide antibody to the carboxy-terminal region of the human PTH receptor type ...

To cite: Callus R, Pullicino R, Buhagiar L, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2014205110 DESCRIPTION A 60-year-old woman with end-stage renal disease secondary to adult polycystic kidney disease, presented with a 6-month history of worsening sacral and rectal pain. She reported anorexia and significant weight loss. She was on haemodialysis for...

The aim of this study was to determine the maximum tolerated dose of YDOTATOC per cycle administered in association with amino acid solution as kidney protection in patients with somatostatin receptorpositive tumours. Forty patients in eight groups received two cycles of Y-DOTATOC, with activity increased by 0.37 GBq per group, starting at 2.96 and terminating at 5.55 GBq. All patients received...

BACKGROUND Birt-Hogg-Dubé syndrome (BHDS) (MIM 135150) is an autosomal dominant predisposition to the development of follicular hamartomas (fibrofolliculomas), lung cysts, spontaneous pneumothorax, and kidney neoplasms. Germline mutations in BHD are associated with the susceptibility for BHDS. We previously described 51 BHDS families with BHD germline mutations. OBJECTIVE To characterise the ...

Renal malignancy is the 15th leading cause of annual deaths, with late detection and misdiagnosis to decreased patient survival. We hereby present three cases malignant renal tumours which grabbed our attention because their rarity interesting presentation. Case 1-A 38 year old male presented palpable lump in right flank, CT revealed a multilocular cystic lesion kidney, along horse-shoe kidneys...

Renal cell carcinoma (RCC) is the fifth most common malignancy in kidney transplant recipients, with increased risk arising due to immunosuppression. De novo RCC occurrence in kidney allografts is much less common when compared with the native kidneys. Multifocal RCC in allograft kidneys is rarely described. In this report, we discuss two cases of de novo multifocal renal neoplasms in allograft...