Kidney allograft rejection is associated with infiltration of inflammatory CD11b+ leukocytes. A CD11b agonist leukadherin-1 (LA1) increases leukocyte adhesion, preventing their transmigration and tissue recruitment in vivo. Here, we test the extent to which LA1-mediated activation of CD11b/CD18 enhances kidney allograft survival in a mouse model of fully MHC-mismatched orthotopic kidney transpl...

Renal functional reserve (RFR) represents the capacity of the kidney to increase glomerular filtration rate (GFR) in response to certain physiological or pathological stimuli or conditions. Once baseline GFR is determined, RFR can be assessed clinically after an oral protein load or intravenous amino acid infusion. In clinical practice, baseline GFR displays variable levels due to diet or other...

OBJECTIVES To determine how many kidney function tests are done, on whom, how frequently they are performed and how they have changed over time. DESIGN Retrospective study of all serum creatinine, urine albumin and urine creatinine tests. SETTING Primary and secondary care in Oxfordshire from 1993 to 2013. PARTICIPANTS Unselected population of 1,220,447 people. MAIN OUTCOME MEASURES The...

recognition of typhoid hepatitis is important since it has to be differentiated from other common ailments in our country such as viral, malarial or amoebic hepatitis. early institution of specific therapy in cases of typhoid hepatitis carries a good prognosis. in our study, 107 patients with positive blood or bone marrow cultures for salmonella typhi, were evaluated for hepatomegaly and abnorm...

introduction: recently a relation between female sex hormones and severity of asthma symptoms has been proposed. as a common endocrine dysfunction, polycystic ovary syndrome (pcos) could significantly influence the level of sex hormones in pcos patients. regarding the possible role of sex hormones in airway physiology, the present study was conducted to survey the effects of pcos on pulmonary f...

introduction:  asthma exacerbation is common in children. treatment with oral corticosteroids (ocs) and inhaled corticosteroids are suggested for asthma exacerbation. it is shown that inhaled corticosteroids has similar outcome in reducing asthma symptoms compared to ocs. but few studies have evaluated the pulmonary function changes in these two treatments. in this study, we evaluated the chang...

introduction the dexamethasone test has been widely used for diagnosing hypercortisolism. materials and methods we assessed the relationship between the basal and suppressed cortisol values in urine and plasma during a low-dose dexamethasone test in patients with proved cushing&apos;s disease. results a statistically highly significant correlation was found (for urine cortisol: r = 0.66, p <0.0...

Background: Hypertension is one the most common causes of chronic kidney disease (CKD). One of the major concerns in hypertensive patients is early detection of renal disorders. In the past, serum creatinine (Scr) concentration was used as a marker of kidney function, but it proffers a late reflection of reduced glomerular filtration rate. Cystatin C and neutrophil gelatinase-associated lipocal...

Renal functional reserve (RFR) represents the capacity of the kidney to increase glomerular filtration rate (GFR) in response to certain physiological or pathological stimuli or conditions. Once baseline GFR is determined, RFR can be assessed clinically after an oral protein load or intravenous amino acid infusion. In clinical practice, baseline GFR displays variable levels due to diet or other...