OBJECTIVES To apply the RIFLE criteria "risk," "injury," and "failure" for severity of acute kidney injury to patients admitted to the intensive care unit and to evaluate the significance of other prognostic factors. DESIGN Retrospective analysis of the Riyadh Intensive Care Program database. SETTING Riyadh Intensive Care Unit Program database of 41,972 patients admitted to 22 intensive car...

Citation: Das F. Identify the Underlying Mechanisms Driving the Pathogenesis of Diabetic Nephropathy. Adv kidney Dis Treat. 2016, 1:1. My research focuses on understanding the cellular and molecular mechanisms of different types of kidney disease and to identify the signalling pathways that regulate kidney disease. Understanding the components in these signalling pathways and their mechanisms o...

Background: Chronic kidney disease (CKD) is now regarded as a global public health epidemic. Management of chronic kidney disease is often beyond the reach of some patients especially in resource-poor countries of sub-Saharan Africa where patients have to bear the funding. Many Nigerians do not know the functions of the kidney, the symptoms of kidney diseases and the causes of kidney failure. A...

BACKGROUND Recent guidelines suggest lowering the target blood pressure for patients with chronic kidney disease, although the strength of evidence for this suggestion has been uncertain. We sought to assess the renal and cardiovascular effects of intensive blood pressure lowering in people with chronic kidney disease. METHODS We performed a systematic review and meta-analysis of all relevant...

BACKGROUND Carbon monoxide, albeit common, is rarely associated with renal failure. We report a case of CO-associated kidney failure requiring short-term dialysis. CASE REPORT A 33 year-old male was found unconscious in a bathroom equipped with a propane-gas heater. The duration of exposure to carbon monoxide was unknown. The patient was transported to a regional hyperbaric centre;the carboxy...

AIM To assess outcomes of kidney transplantation including patient and allograft outcomes in recipients with hepatitis B virus (HBV) infection, and the trends of patient's outcomes overtime. METHODS A literature search was conducted using MEDLINE, EMBASE and Cochrane Database from inception through October 2017. Studies that reported odds ratios (OR) of mortality or renal allograft failure af...

CONTEXT Chronic kidney disease (CKD) is common. Kidney disease severity can be classified by estimated glomerular filtration rate (GFR) and albuminuria, but more accurate information regarding risk for progression to kidney failure is required for clinical decisions about testing, treatment, and referral. OBJECTIVE To develop and validate predictive models for progression of CKD. DESIGN, SE...

AIMS There is growing recognition of the clinical importance of cardiorenal syndrome-the bidirectional interplay between kidney and cardiac dysfunction. Yet, the role of kidney tubular damage in the development of heart failure is less studied. The objective of this study was to investigate whether urinary kidney injury molecule (KIM)-1, a specific marker of tubular damage, predisposes to an in...