UNLABELLED Tuberous sclerosis complex (TSC) is an autosomal disease caused by inactivating mutations in either of the tumor suppressor genes TSC1 or TSC2. TSC-associated tumor growth is present in multiple tissues and organs including brain, kidney, liver, heart, lungs, and skin. In the kidney, TSC angiomyolipomas have aberrant vascular structures with abnormal endothelial cells, suggesting a r...

We compared large artery mechanical properties in children with nondialysis stages of chronic kidney disease with those in children with normal renal function, examining the potential effect of blood pressure (BP) components and level of renal dysfunction. Common carotid artery mechanical properties, carotid-femoral pulse wave velocity, and carotid and peripheral BP were measured in children (n...

BACKGROUND/AIMS To investigate the role of endothelial dysfunction on left ventricular remodeling in patients with chronic kidney disease and to evaluate the correlation between endothelial dysfunction and left ventricular remodeling. METHODS Seventy-three patients with chronic kidney disease as study-group and thirty healthy volunteers as control-group were enrolled in the present study. All...

Fig. 8 was not corrected before publication. The correct figure appears below. We apologise to the authors and readers for this mistake. 2099 RESEARCH ARTICLE INTRODUCTION Kidney development serves as a model for examining the mechanisms that underlie organogenesis, including cellular aggregation, polarization, differentiation and mesenchymal-epithelial interactions. Key processes in kidney dev...

The Weinbaum-Jiji equation can be applied to situations where: 1) the vascular anatomy is know; 2) the blood velocities are known; 3) the effective modeling volume includes many vessels; and 4) the vessel equilibration length is small compared to the actual length of the vessel. These criteria are satisfied in the situation where steady-state heated thermistors are placed in the kidney cortex. ...

Nanoparticles are being investigated for numerous medical applications and are showing potential as an emerging class of carriers for drug delivery. Investigations on how the physicochemical properties (e.g., size, surface charge, shape, and density of targeting ligands) of nanoparticles enable their ability to overcome biological barriers and reach designated cellular destinations in sufficien...

OBJECTIVE In this study we planned to investigate the relationship between presence of kidney stones and stone burden with hypertension (HT), diabetes mellitus (DM) and body mass index (BMI). METHODS A total of 574 patients were included in the study. None of the patients had a history of stones. The 121 patients with kidney stone identified on ultrasound evaluation and the 453 patients with ...

CONTEXT Tissue sampling of renal masses is traditionally performed via the percutaneous approach or laparoscopicaly. The utility of endoscopic ultrasound to biopsy renal lesions it remains unclear and few cases have been reported. OBJECTIVES To evaluate the feasibility and outcome of endoscopic ultrasound fine needle aspiration of renal tumors. METHODS Consecutive subjects undergoing attemp...

PURPOSE OF REVIEW Polycystic kidney disease (PKD) is the most common genetic cause of chronic renal failure. Mouse models of PKD, especially those with mutations in genes that are orthologous to human disease genes, have provided insights into the pathogenesis of cyst formation and advanced the preclinical testing of new drugs. RECENT FINDINGS PKD is a ciliopathy that arises from abnormalitie...

Although we recently clarified sex-based differences in mouse kidney morphology, the developmental processes responsible for these gender differences during maturation remain unclear. The present study analyzed the morphometry of kidneys from 20-, 30-, 50-, 60-, 70-, 90-, 120- and 150-day-old DBA/2Cr mice. Total kidney weight and ratio of kidney weight to body weight were larger in males than f...