OBJECTIVES To review the literature on diseases linked with infection by human T-cell lymphotropic virus type I (HTLV-I) in childhood and adolescence, with focus on clinical aspects, diagnosis, pathogenesis, progression and treatment. SOURCES Medical literature published during the last 20 years identified using PubMed and MEDLINE and from specialized medical books, with emphasis on infective...

The Albuquerque branch of the United Blood Services system was found to have an unusually high blood donor human T-cell leukemia/lymphoma virus (HTLV) seroprevalence (0.72 per 1,OOO). Many studies investigating HTLV seroprevalence and transmission have assumed that all seropositivity is due to HTLV type I (HTLV-I); recent data dispute this conclusion. We investigated the high prevalence of HTLV...

BACKGROUND AND OBJECTIVES Lymphoma is the fourth most frequent malignancy diagnosed during pregnancy, occurring in approximately 1 over 6000 deliveries. DESIGN AND METHODS Its occurrence may increase due to the current trend to postpone pregnancy until later in life and the evidence suggested high incidence of AIDS-related non-Hodgkin's lymphoma in developing countries. The relatively rare oc...

To the Editor—We read with interest the brief report by Barzon et al [1] showing that WU and KI polyomaviruses (WUPyV and KIPyV) reactivate and are frequently detectable in the brains of human immunodeficiency virus (HIV)–positive patients without being associated with progressive multifocal leukoencephalopathy. We also recently disproved such an association between novel polyomaviruses (includ...

Human T-lymphotropic virus type 1 (HTLV-1) was the first human oncovirus isolated by Gallo et al. in 1980 and established as an etiological agent for adult T-cell leukemia/ lymphoma (ATL). Although more than 15 million individuals are infected by HTLV-1 through the world, the spread of the virus is highly endemic. The HTLV-1 infection is prevailing in southwestern Japan, inter-tropical Africa, ...

The discovery of lymphoid B-Iymphotropic herpesvirus-producing cell lines from M. arctoides peripheral lymphocytes (MAL-l) producing their own lymphotropic virus HVMA was reported earlier [1]. Subsequently, two more M. arctoides virus-producing lymphoid cell lines (MAL-2, MAL-3) were discovered in our laboratory. The cells of some baboon lymphoid cultures, parallel with B-Iymphotropic herpesvir...

BACKGROUND Human T-cell lymphotropic virus type 1 (HTLV-1) screening of blood and organ donors is not mandatory in Germany because of its low prevalence (about 7/100 000). An HTLV-1 transmission event caused by a multiple organ donor was investigated. Validity of diagnostic procedures and HTLV-1 disease association in immunosuppressed organ recipients were analyzed. METHODS Two screening immu...