The tablets manufactured by direct compression method using co-processed excipient showed relatively better disintegration time and in vitro drug release, with omission of number of laborious steps as compared to tablets manufactured by conventional wet granulation method. Melt granulation technique is a potential alternative for the development of directly compressible adjuvants. Lactose and m...

Two simple, accurate and reproducible methods were developed and validated for the simultaneous determination of paracetamol (PARA) and pamabrom (PAMB) in pure form and in tablets. The first method was based on reserved-phase high-performance liquid chromatography, on a Thermo Hypersil ODS column using methanol:0.01 M sodium hexane sulfonate:formic acid (67.5:212.5:1 v/v/v) as the mobile phase....

OBJECTIVE This study compared the efficacy and safety of low-dose 7-day buprenorphine patches and prolonged-release tramadol tablets in patients with chronic, moderate to severe osteoarthritis (OA) pain of the hip and/or knee. METHODS Eligible patients were adults with a clinical and radiologic diagnosis of OA of the hip and/or knee and moderate to severe pain, as confirmed by a mean Box Scal...

Paracetamol (acetaminophen) is one of the most commonly used drugs for the treatment of pain and fever in children, both at home and in the clinic, and is now also found in the environment. Paracetamol is known to act on the endocannabinoid system, involved in normal development of the brain. We examined if neonatal paracetamol exposure could affect the development of the brain, manifested as a...

INTRODUCTION
 Paracetamol is one of the most widely used analgesics and antipyretics in world. An overdose this drug can occur after a single ingestion large amount paracetamol or repeated smaller amounts that eventually exceed recommended total dose result liver damage. It believed maximum daily for an adult 4g.
 MATERIALS AND METHOD
 Patient information was collected from hospi...

Paracetamol (acetaminophen) is widely used as an over-the-counter analgesic and antipyretic drug. The aim of this study was to investigate the possible protective effects of vitamin C (100mg/kg/day i.p.) and β-glucan (40 mg/kg/day i.p.) on altered haematological, biochemical and oxidative stress parameters in the blood of rats treated with paracetamol (100 mg/kg/day i.p.) for 3 days. Exposure o...

OBJECTIVE To assess whether measuring plasma paracetamol concentrations in all patients with drug overdose or collapse (altered consciousness) changes outcome. METHOD A retrospective survey was performed of all patients attending the Accident and Emergency Department at Guy's Hospital, London over a 12 month period who had plasma paracetamol concentrations measured (it is hospital policy that...