TNPM presents as subcorneal or intraepidermal pustules composed mainly of neutrophils; this finding helps to differentiate TNPM from NTE, in which there is a predominance of eosinophils. In conclusion, we must be aware that TNPM is a benign condition with no systemic manifestations and it does not require treatment. This entity can be confused with serious infections, and patients with TNPM may...

TNPM presents as subcorneal or intraepidermal pustules composed mainly of neutrophils; this finding helps to differentiate TNPM from NTE, in which there is a predominance of eosinophils. In conclusion, we must be aware that TNPM is a benign condition with no systemic manifestations and it does not require treatment. This entity can be confused with serious infections, and patients with TNPM may...

An automated synthesis system using a solid-phase extraction (SPE) system and column packed with octadecylsilica (ODS), which was coated with phospholipid and loaded with dog liver microsomes, was developed for synthesis of glucuronides. Preparation of the microsome-immobilized SPE column, glucuronidation of drugs to synthesize the glucuronides and elution of the products were performed by an a...

OBJECTIVE To investigate the management of menorrhagia in primary care and its impact on referral and hysterectomy rates. DESIGN Prospective observational study. SETTING 11 general practices from the Somerset Morbidity Project. SUBJECTS 885 women consulting their general practitioner with menorrhagia over four years. MAIN OUTCOME MEASURES Proportions of these women investigated and trea...

To investigate the hypothesis that molecules acting as crystallization inhibitors in solution could be transformed into crystallization promoters, additives were synthesized that mimic the pharmaceuticals acetaminophen and mefenamic acid and also possess polymerizable functionality. It was found that, in solution, these additives face-selectively inhibit crystal growth and lead to overall slowe...

Background and objectives: Primary dysmenorrhea has remained a health problem. This study has compared the effect of oral and topical ginger on severity and duration of primary dysmenorrhea. Methods: A single-blind randomized trial was conducted on 70 female students with moderate and severe primary dysmenorrhea. The participants were stratified randomized between two groups of oral and topical...

BACKGROUND Menorrhagia (heavy menstrual bleeding) is a benign yet debilitating social and health condition. Treatments prescribed in order to reduce excessive menstrual blood loss include prostaglandin synthetase inhibitors, antifibrinolytics, the oral contraceptive pill and other hormones. The combined oral contraceptive pill (OCP) is claimed to have a variety of beneficial, inducing a regular...

Guest-host complex formation of three drug derivatives of anthranilic acid, mefenamic acid, niflumic acid, and flufenamic acid with 2-hydroxypropyl-β-cyclodextrin (2HP-β-CD) in aqueous solutions was investigated using "Phase solubility study" with UV-vis spectrophotometry. Solubility of sparingly soluble drugs has been improved by addition of 2HP-β-CD at two temperatures 298.15 K and 310.15 K a...