objective(s): exposing to stress may be associated with increased production of reactive oxygen species (ros). therefore, high level of oxidative stress may eventually give rise to accumulation of oxidative damage and development of numerous neurodegenerative diseases. it has been presented that brain-derived neurotrophic factor (bdnf) supports neurons against various neurodegenerative conditio...

Age-related cataract, an opacity of the eye lens, is the leading cause of visual impairment in the elderly, the etiology of which is related to oxidative stress damage. Oxidation of methionine to methionine sulfoxide is a major oxidative stress product that reaches levels as high as 60% in cataract while being essentially absent from clear lenses. Methionine oxidation results in loss of protein...

BACKGROUND Oxidative stress is a key feature in the pathogenesis of several neurological disorders. Following oxidative stress stimuli a wide range of pathways are activated and contribute to cellular death. The mechanism that couples c-Jun N-terminal kinase (JNK) signaling, a key pathway in stress conditions, to the small ubiquitin-related modifier (SUMO), an emerging protein in the field, is ...

UNLABELLED Increased oxidative stress is associated with various diseases and aging, while adaptation to heat stress is an important determinant of survival and contributes to longevity. However, the impact of oxidative stress on heat resistance remains largely unclear. AIM In this study we investigated how oxidative stress impinges on heat stress responses. RESULTS We report that hydrogen-...

Oxidative stress is a key contributor to the development of cardiovascular diseases. Bioactive dietary elements including phytochemicals, and in particular, carotenoids display antioxidant effect and substantially reduce markers of oxidative stress. Carotenoids have been shown to prevent several chronic disorders including cardiovascular diseases by reducing the inflammatory responses. Here, we...

o bjective : increased levels of oxidative stress markers in periodontitis have been reported by recent studies. malondialdehyde (mda) and superoxide dismutase (sod) are both in- creased during oxidative stress. the aim of this study was to detect and measure the level of oxidative stress markers in peri-implant crevicular fluid (picf). their correlation with peri-implant clinical parameters wa...

background: the present study was carried out to investigate the possible protective effects of royal jelly (rj) on oxymetholone (oxm)-induced oxidative liver injuries in mice. methods: in total, 32 adult male nmri mice were divided into four groups of eight mice each. mice in groups 1 and 2 were orally administered 5 mg/kg/day oxm for 30 days. at the same time, mice in group 3 received rj at a...

conclusions with regard to the potent antioxidant properties of silymarin, the neuroprotective effects of this natural compound suggested in the current study may in part be mediated through inhibition of oxidative stress. results exposure to acr reduced cell viability in pc12 cells. pre-treatment of cells with silymarin (100 µm) significantly reduced acr-induced toxicity. in addition, administ...

in the present study, free-radical-scavenging and antioxidant activities of angipars™, an herbal extract which has been registered as a therapeutic drug for diabetic foot ulcer, were examined. we investigated the protective effect of angipars™ on cytotoxicity produced by exposure to h2o2 (300 µm) in hepg2 and a549 cell lines, using mtt assay, glutathione (gsh) content analysis, and lipid peroxi...

propionic acid (pa) is a short chain fatty acid, a common food preservative and metabolic end product of enteric bacteria in the gut. the present study was undertaken to investigate the effect of pa on liver injury in male rats. male western albino rats were divided into two groups. the first group served as normal control, the second was treated with pa. the activities of serum hepatospecific ...