Passive muscle stretch performed during a period of post-exercise muscle ischemia (PEMI) increases muscle sympathetic nerve activity (MSNA), and this suggests that the muscle metabolites may sensitize mechanoreceptors in healthy humans. However, the responsible substance(s) has not been studied thoroughly in humans. Human and animal studies suggest that cyclooxygenase products sensitize muscle ...

The relative contributions of endothelium-dependent dilators [nitric oxide (NO), prostaglandins (PGs), and endothelium-derived hyperpolarizing factor (EDHF)] in human limbs are poorly understood. We tested the hypothesis that relative contributions of NO and PGs differ between endothelial agonists acetylcholine (ACh; 1, 2, and 4 microg.dl(-1).min(-1)) and bradykinin (BK; 6.25, 25, and 50 ng.dl(...

conclusions paracetamol 1 g stat + 3 g/24 h infusion is as effective as ketorolac 30 mg stat + 90 mg/24 h infusion in post-vats pain management, with good tolerability and a low incidence of adverse effects. results there was no significant difference between the k and p groups in pain scores in any of the evaluations. seventeen (48.6 %) and 9 (25.7 %) patients in the k and p groups, respective...

the present study was undertaken to develop a suitable transdermal matrix patch of ketorolac tromethamine with different proportions of polyvinyl pyrrolidone (pvp) and ethyl cellulose (ec) using a d-optimal mixture design. the prepared transdermal patches were subjected to different physicochemical evaluation. the surface topography of the patches was examined by scanning electron microscopy (s...

Key points † After total knee arthroplasty, local infiltration analgesia (LIA) with intra-articular ketorolac and morphine was superior to epidural anaesthesia after the initial 24 h. † Epidural anaesthesia offered better initial pain relief, despite more common side-effects such as hypotension at the post-anaesthetic care unit. † Ketorolac and morphine showed a superior therapeutic balance whe...

INTRODUCTION With the increase in the number of total knee surgeries being performed, postoperative analgesic management remains a challenge. We used a new animal knee surgery model to characterize pain-related behavior in the rat, and its therapeutic modulation with systemic and intrathecal drug treatment. METHODS Rats were anesthetized with isoflurane and an incision was made over the left ...

Results: On the hot plate model ED50 value was per body weight 0.34 (0.18 0.63) mg/kg of the pyrodazol /i.g, 1.00 (0.59 1.70) mg/kg/of the ketorolac/ i. g. in 90 minutes post administration. On the hot plate model in 0.3 1.3 mg/kg/doses i.m the pirodazol is similar to morphine hydrochloride in dose 2.5 mg/kg i.m. On the tail-flick model ED50 values of the pyrodazol and ketorolac are 1.9 (1.12 3...