Mutations of isocitrate dehydrogenase 1 (IDH1) are frequently found in certain cancers such as glioma. Different from the wild-type (WT) IDH1, the mutant enzymes catalyze the reduction of α-ketoglutaric acid to d-2-hydroxyglutaric acid (D2HG), leading to cancer initiation. Several 1-hydroxypyridin-2-one compounds were identified to be inhibitors of IDH1(R132H). A total of 61 derivatives were sy...

The nonvolatile orgainic acicls uncloubte(dly play a role in fruit ripening as they (1o in many other metabolic processes. As an approach to definiing this role in the banania fruit, informatioin is needled on the nature of these acids and on the chainges which occur dluring ripening. Earlier reports (23) indicate the presence of nmalic, citric, oxalic, an(l tartaric acids in the banana fruit, ...

ROSE, DAVID M., JOSEPH DISALVO, AND SULAMITA BALAGURABARUCH. Renal glucose production in the intact dog. Am. J. Physiol. 218(6): 1676-1681. 1970.-Renal glucose production was studied in anesthetized fasting (18 hr) dogs, in various states of acid-base balance, by two procedures: a) by measuring the difference of glucose concentration in renal venous and arterial plasma, using the standard gluco...

An enzyme which catalyzes the aromatization of cyclohexanecarboxyl coenzyme A has been isolated from whole liver as well as from liver mitochondria. Incubation of the soluble, partially purified enzyme with cyclohexanecarboxyl-CoA produces cyclohexene-l-carboxyl-CoA, benzoyl-CoA, and a polar compound which has not. been further characterized. All three isomers of cyclohexenecarboxyl-CoA are con...

Apart from the observation by Alsberg (1911) that gluconic acid is produced from glucose by Phytomonas savastanoi, the oxidative metabolism of fluorescent pseudomonads has received little attention until very recently. For the most part it has been tacitly assumed that these org Ims, by virtue of their obligately aerobic nature, carry out a complete mineralization of organic substrates (den Doo...

Liver fibrosis is a common stage in the majority of chronic liver diseases, regardless of the etiology, and its progression may lead to hepatic cirrhosis or hepatocellular carcinoma. Metabolomics, a powerful approach in systems biology, is a discipline used to qualitatively and quantitatively analyze the small molecule metabolites of cells at specific times and under certain conditions. The pre...