Scientists and patients are keen to apply new experimental techniques to human diseases, especially currently untreatable progressive neurodegenerative diseases, of which multiple system atrophy (MSA) is an example. We argue that it behooves us to first have robust preclinical experimental evidence before launching into such studies in humans, and to control as much as possible for confounding ...

Wil is a writer, teacher, learning technologist and keen language learner. teachers in using classroom and web technology, and written e-learning materials for or who are used to the traditional 'teacher and class' model of education. and online learning, in the hands of a welltrained teacher, both delivery methods. Setting plays a crucial role in effective teaching, and learning and eLearning ...

We consider complex Fenchel–Nielsen coordinates on the quasi-Fuchsian space of punctured tori. These coordinates arise from a generalisation of Kra’s plumbing construction and are related to earthquakes on Teichmüller space. They also allow us to interpolate between two coordinate systems on Teichmüller space, namely the classical Fuchsian space with Fenchel–Nielsen coordinates and the Maskit e...

TAGS is an inter-disciplinary, inter-institutional project which brings together software systems builders and subject-specialists keen to exploit network based learning. It is sponsored by SHEFC as part of a wider C&IT programme [1]. The project has developed a web-based system for group-based project work where all types of resource are groupbased. This paper gives an overview of the user mod...

The NMR detection of methyl groups is of keen interest because they provide the long-range distance information required to establish global folds of high molecular weight proteins. Using longitudinal H relaxation optimization, we achieve a gain in sensitivity of approximately 1.6-fold in the methyl-TROSY and its NOESY experiments for the 38 kDa protein mitogen activated protein kinase p38 in i...

LAST October the Birmingham Association for Mental Health held a one-d; Conference on "The Psychotic Child" which met with such an enthusiaf response that it had to move its meeting place to the larger hall at the Univers1' which was packed with over 600 people. The current keen interest in the subF itself and the imposing names on the programme combined to attract staff ff? child guidance clin...

This summer project reproduces the foam experiment from previous summer but with oilwater emulsions. Increasing the viscosity of oil changes the droplets from soft to hard as well as the behavior from Newtonian liquid to granular matter. The expected outcome is Bachelor’s or Master’s Thesis or similar report depending on applicant’s background. The applicant is expected to have keen interest in...

Long-term outcome after haploidentical stem cell transplant and infusion of T cells expressing the inducible caspase 9 safety transgene Xiaoou Zhou, Antonio Di Stasi, Siok-Keen Tey, Robert A. Krance, Caridad Martinez, Kathryn S. Leung, April G. Durett, Meng-Fen Wu, Hao Liu, Ann M. Leen, Barbara Savoldo, Yu-Feng Lin, Bambi J. Grilley, Adrian P. Gee, David M. Spencer, Cliona M. Rooney, Helen E. H...

Oxazolones are five membered heterocyclic compounds containing nitrogen and oxygen as hetero atoms. The C-2 and C-4 positions of the oxazolone are crucial for their various biological activities. N-substituted oxazolones also participated in variety of intermolecular reactions. Considering these properties, various research workers have shown a keen interest in this small heterocyclic moiety as...

Orthodontists, thanks to their keen appreciation of facial morphology and their skills in making functional examinations, are ideally placed to detect breathing problems in their patients that can require an ENT assessment, with special attention paid to the evaluation of sleep patterns. After a site of obstruction, resulting from a soft tissue anomaly and/or a narrowing of the airway passage t...