El Síndrome de Wolfram (WS), el síndrome Kearns-Syre (SKS) y la degeneración macular relacionada a edad (DMAE), aunque comparten manifestaciones clínicas similares maculopatía, etiología genética las características oftalmológicas suelen diferir. Se describen coincidencias etiopatogénicas diferencias oftalmológicas. En WS se presenta pérdida gradual visión alteraciones en percepción colores sec...

We study the complexity of learning in Kearns’ well-known statistical query (SQ) learning model (Kearns, 1993). A number of previous works have addressed the definition and estimation of the information-theoretic bounds on the SQ learning complexity, in other words, bounds on the query complexity. Here we give the first strictly computational upper and lower bounds on the complexity of several ...

In this paper, we introduce and examine two new models for competitive contagion in networks, a game-theoretic generalization of the viral marketing problem. In our setting, firms compete to maximize their market share in a network of consumers whose adoption decisions are stochastically determined by the choices of their neighbors. Building on the switching-selecting framework introduced by Go...

The purpose of this study was to compare the clinical effects of patelloplasty and traditional patellar management in total knee arthroplasty (TKA) for osteoarthritis. A total of 152 patients with osteoarthritis treated with TKA between January 2004 and December 2005 were retrospectively studied. The patients were randomly divided into 2 groups: the patelloplasty group (group A; n=76) and the t...

The ACORN system was originally developed as a means of ab initio solution of protein structures when atomic resolution data were available. The first step is to obtain a starting set of phases, which must be at least slightly better than random. These may be calculated from a fragment of the structure, which can be anything from a single metal atom to a complete molecular-replacement model. A ...