نتایج جستجو برای: kc

تعداد نتایج: 3662  

Journal: :Journal of clinical pathology 1996
A M van den Besselaar R H Peters

AIM To compare the International Sensitivity Index (ISI) of the Thrombotest reagent used with a steel ball coagulometer (KC) to the ISI of the same reagent used with the manual (tilt tube) technique. METHODS The study was carried out by eight laboratories using their own KC instrument and method of testing. All laboratories used the same batch of Thrombotest to determine the clotting times of...

Journal: :Journal of immunology 2000
Y Luo F R Fischer W W Hancock M E Dorf

Astrocytes are specialized cells of the CNS that are implicated in the pathogenesis of multiple sclerosis and experimental allergic encephalomyelitis. In acute and relapsing-remitting experimental allergic encephalomyelitis, the neutrophil chemoattractant CXC chemokines macrophage-inflammatory protein (MIP)-2 and KC are associated with reactive astrocytes in the parenchyma. In vitro treatment o...

Journal: :Advances in Fuzzy Systems 2018

2007
Kerstin Abshagen Christian Eipel Jörg C. Kalff Michael D. Menger Brigitte Vollmar

Kupffer cells (KCs) are located in the liver sinusoids adjacent to hepatocytes and are capable of producing important growth-regulating mediators which exert both stimulatory and inhibitory influences on hepatocyte proliferation by paracrine mechanisms. To elucidate the overall effect of KC-depletion on liver regeneration, mice were selectively and long-standing depleted of KCs by liposome-enca...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2007
Michael Frink Bjoern M Thobe Ya-Ching Hsieh Mashkoor A Choudhry Martin G Schwacha Kirby I Bland Irshad H Chaudry

Neutrophil infiltration is a key step in the development of organ dysfunction following trauma-hemorrhage (T-H). Although we have previously shown that 17beta-estradiol (E2) prevents neutrophil infiltration and organ damage following T-H, the mechanism by which E2 inhibits neutrophil transmigration remains unknown. We hypothesized that E2 prevents neutrophil infiltration via modulation of kerat...

Journal: :Biological research 2010
Giovani M Favero Raul C Maranhão Durvanei A Maria Débora Levy Sérgio P Bydlowski

7-ketocholesterol (7-KC) differs from cholesterol by a functional ketone group at C7. It is an oxygenated cholesterol derivative (oxysterol), commonly present in oxidized low-density lipoprotein (LDL). Oxysterols are generated and participate in several physiologic and pathophysiologic processes. For instance, the cytotoxic effects of oxidized LDL have been widely attributed to bioactive compou...

2003
Patrice Klein Stefan Llewellyn Smith

We study the dispersion of wind-induced near-inertial oscillations (NIOs) in a fully turbulent baroclinicmesoscale eddy Ž eld characterizedby a continuouswavenumber spectrum. The in uence of the eddy Ž eld on the horizontal dispersion of the differentNIO modes is analyzed using a vertical normal mode expansion. Previous studies have identiŽ ed two dispersion regimes: trapping and strong disper...

2014
Kurt Bachmaier Sophie Toya Asrar B. Malik

Myocarditis, often due to an aberrant immune response to infection, is a major cause of dilated cardiomyopathy. Microbial pattern recognition receptors, such as TLRs, orchestrate the cytokine and chemokine responses that augment or limit the severity of myocarditis. Using the mouse model of experimental autoimmune myocarditis (EAM), in which disease is induced by immunization with a heart-speci...

2013
Adarsh S. Reddy Jigisha R. Patel Carole Vogler Robyn S. Klein Mark S. Sands

Globoid-cell Leukodystrophy (GLD; Krabbe's disease) is a rapidly progressing inherited demyelinating disease caused by a deficiency of the lysosomal enzyme Galactosylceramidase (GALC). Deficiency of GALC leads to altered catabolism of galactosylceramide and the cytotoxic lipid, galactosylsphingosine (psychosine). This leads to a rapidly progressive fatal disease with spasticity, cognitive disab...

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2007
Michael Frink Ailing Lu Bjoern M Thobe Ya-Ching Hsieh Mashkoor A Choudhry Martin G Schwacha Steven L Kunkel Irshad H Chaudry

Leukocyte infiltration, mediated by chemokines, is a key step in the development of organ dysfunction. Lung and liver neutrophil infiltration following trauma-hemorrhage is associated with upregulation of monocyte chemoattractant protein-1 (MCP-1). Because MCP-1 is not a major attractant for neutrophils, we hypothesized that MCP-1 influences neutrophil infiltration via regulation of keratinocyt...

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