Introduction: It has recently been suggested that the KATP channel subunits Kir6.x and BKCa channels exist in the endoplasmic reticulum of cardiomyocytes and neurons. Our previous studies showed the electrophysiological behavior of cation channels in the rough endoplasmic reticulum (RER) of rat hepatocytes. Therefore, we hypothesized that KATP channels and Ca2+-activated potassium channels m...

1. The cytological and cytochemical properties of the Ehrlich tetraploid and hyperdiploid, TA3 tetraploid and diploid, Krebs 2B, sarcoma 37, MC1M, 6C3HED and DBA lymphoma, and lymphoma #1 ascites tumors at a fixed interval after transplantation are described. 2. No qualitative differences were observed in the cytochemical properties of the nucleus, nucleolus, parachromatin, parachromatin bodies...

OBJECTIVES This study intends to provide a quick, easy, and inexpensive way to assess nuclear abnormalities such as micronuclei and bud frequencies; binucleated, karyorrhectic, karyolytic, pycnotic, and condensed chromatin cells in nasal scrapings of infants, which are particularly important for conducting genotoxic studies related to the inhaled atmosphere in pediatric populations. METHODS N...

Kikuchi-Fujimoto disease (KFD) is an extremely rare disease with a worldwide distribution and higher prevalence in Asians. It is a benign and self-limiting disorder, characterized by regional cervical lymphadenopathy accompanied with mild fever and night sweats. Lymph node histopathology is diagnostic and treating physicians should be aware of this entity as it may mimic other systemic diseases...

This study was conducted to determine optimal ratios of dietary linolenic acid (18:3n-3, LnA) to linoleic acid (18:2n-6, LA) for Tor tambroides. Juveniles were fed three trial diets with different ratios of LnA/LA (0.0, 0.5 and 1.0) for 10 weeks. Another diet contained 100% palm oil, which was similar tothe diet with 0.0 LnA/LA ratio but different in total amounts of C18polyunsaturated fatty ac...

cellsderived from wharton’s jelly have been reported to display a wide multilineagedifferentiation potential, showing some similarities to both embryonic (esc)and mesenchymal stem cells (mscs). the present study investigated thedifferentiation potential of human umbilical cord mesenchymal stem cells(ucmscs) into hepatic lineage through embryonic body- like aggregates formationin the presence of...

Background: Liver fatty acid-binding protein (L-FABP) is the main cytosolic binding site for long chain fatty acids in hepatocytes. FABPs enhance the uptake of fatty acids into the cell by increasing their concentration due to decreasing concentration of unbound fatty acids inside the cell. Objectives: The aim of this study was to evaluate the effects of dietary unsaturated to saturated fatty a...

In this research, we investigated the cytotoxic mechanisms of Cochlodinium polykrikoidescell lysate on isolated rat liver hepatocytes.This micro algae is responsible for a severe and widespread harmful algal bloom in the Persian Gulf and Gulf of Oman (2008-2009). Isolated hepatocytes were obtained by collagenase perfusion of Sprague-Dawley rat liver.According to our results, incubation of algal...

Concentrative nucleoside transporter 2 (CNT2) (encoded by the SLC28A2 gene) transports various antiviral or antitumor purine nucleoside analogs to be involved in their pharmacokinetics and pharmacological actions. The results of our study showed that mouse hepatocytes hardly expressed CNT2 mRNA and no CNT2-dependent nucleoside uptake was observed, while rat hepatocytes exhibited high CNT2-depen...