Predictive immune biomarker signatures in the tumor microenvironment of melanoma metastases associated with tumor-infiltrating lymphocyte (TIL) therapy Jieqing Chen, Caitlin Creasy, Carlos Antonio Torres-Cabala, Suhendan Ekmekcioglu, Sourindra N Maiti, Charuta Kale, Cara Haymaker, Jason Roszik, Roland L Bassett Jr, Jianhua Hu, Zhiqiang Wang, Wencai Ma, R Eric Davis, Chantale Bernatchez, Patrick...

In this work we introduce a conditional accelerated lazy stochastic gradient descent algorithm with optimal number of calls to a stochastic first-order oracle and convergence rate O( 1 ε2 ) improving over the projection-free, Online Frank-Wolfe based stochastic gradient descent of Hazan and Kale [2012] with convergence rate O( 1 ε4 ).

Papaioannou, Theo; Watkins, Andrew; Mugwagwa, Julius and Kale, Dinar (2015). Industry Associations and the Changing Politics of Making Medicines in South Africa. In: Mackintosh, Maureen; Banda, Geoffrey; Tibandebage, Paula and Wamae, Watu eds. Making Medicines in Africa: the Political Economy of Industrializing for Local Health. International Political Economy. Basingstoke: Palgrave Macmillan, ...

Mersin-Antalya karayolu üzerinde, Anamur'un 6 km. güneydoğusunda, deniz kenarında yer alan Mamure Kalesi'nin oturumu 23.500 m² dir. Kalesinin pek çok Anadolu kalesi gibi antik temeller üzerine inşa edildiği ve kalenin bulunduğu yerde M.S. 3.- 4. yüzyıllarda bir Roma yerleşimi olduğu iddia edilmektedir. Bu kentin adı “Rygmonia” olarak adlandırılmıştır. M.S IV. Yüzyılda Romalılar tarafından yapıl...

Cover crops (CC) are an important low-input strategy in sustainable agricultural systems. The impact of different CC (common vetch, field pea, winter oats, fodder kale, common vetch + oats and pea oats), organic mulch, control treatment-fallow, bio-fertilizer (BF) application, on yield quality sweet maize kernel was evaluated. biomass higher mixtures: as well kale. Kernel its chemical compositi...

Alternative forages can be used to provide valuable home-grown feed for ruminant livestock. Utilising these different forages could affect the manure value and the implications of incorporating these forages into farming systems, needs to be better understood. An experiment tested the hypothesis that applying slurries from ruminants, fed ensiled red clover (Trifolium pratense), lucerne (Medicag...

Leishmaniasis is a major public health problem in various part of world; it has also emerged in new geographic areas and host populations. Visceral infection can remain subclinical or become symptomatic, with an acute, subacute or chronic course. Kala-azar, or visceral leishmaniasis (VL), presents as fever, pancytopenia and hypergammaglobulinaemia. The presence of splenomegaly is characteristic...

Thirty cases of human kala-azar were diagnosed by iliac crest biopsy and myeloculture. Histological analysis of 12 patients showed diffuse thickening of reticulin fibers. To the best of our knowledge, this is the third report describing secondary bone marrow fibrosis (myelofibrosis-like) associated with kala-azar. Patients with positive bone marrow fibrosis (pbmf = 12) were compared to patients...

Although liposomal amphotericin B (AmBisome) is considered as the first-line treatment for New Kala-azar, there is not enough evidence on the dosage formulation in children and its effect on them. Being considered as the safest drug for treatment of Kala-azar, this case of AmBisome-induced avascular necrosis now gives rise to the question; whether it is actually safe enough and if a dosage modi...