نتایج جستجو برای: kai1
تعداد نتایج: 194 فیلتر نتایج به سال:
PURPOSE EGF-stimulated signaling via EGF receptor (EGFR) is important in colorectal tumorigenesis and drug targeting. However, anti-EGFR therapy is not effective in a subset of patients with colorectal cancer, suggesting that unidentified EGF-stimulated pathways might play roles in colorectal cancer. Previously, we identified KAI1 C-terminal interacting tetraspanin (KITENIN) as a metastasis-enh...
BACKGROUND Coordinated differentiation of the endometrial compartments in the second half of the menstrual cycle is a prerequisite for the establishment of pregnancy. Endometrial stromal cells (ESC) decidualize under the influence of ovarian progesterone to accommodate implantation of the blastocyst and support establishment of the placenta. Studies into the mechanisms of decidualization are of...
We have used microcell fusion-mediated chromosomal transfer to in troduce normal human chromosomes into highly metastatic rodent pros tatic cancer cells to map the location of a metastasis suppressor gene(s). Using this approach, several chromosomal regions have been identified that harbor such metastatic suppressor genes, including human chromo some 11 between p11.2—13 (T. Ichikawa etaL, Can...
In the adult mammalian brain, oligodendrocyte progenitors can differentiate into mature oligodendrocytes during remyelination. Mechanisms that regulate migration and differentiation of progenitors are of great importance in understanding normal development and demyelinating/remyelinating conditions. In a microarray analysis comparing adult and neonatal O4-positive (+) cells, we found that the t...
The KAII gene, located on human chromosome llpll.2, suppresses tumor metastasis when expressed in certain cancer cells. To evaluate whether dysregulation of KAU occurs during the progression of human prostatic cancer, protein expression, mutation, and allelic loss of KAII were analyzed using a tissue bank of 98 primary cancers and 32 métas tases. By immunohistochemical staining, high levels of...
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