We improve the generalized upper bound for the k-tuple domination number given in [A. Gagarin and V.E. Zverovich, A generalized upper bound for the k-tuple domination number, Discrete Math. 308 no. 5–6 (2008), 880–885]. Precisely, we show that for any graph G, when k = 3, or k = 4 and d ≤ 3.2, γ×k(G) ≤ ln(δ−k + 2) + ln ( (k − 2)d + ∑k−2 m=2 (k−m) 4min{m, k−2−m} d̂m + d̂k−1 ) + 1 δ − k + 2 n, and,...