Mutations in the K(V)7.2 gene encoding for voltage-dependent K(+) channel subunits cause neonatal epilepsies with wide phenotypic heterogeneity. Two mutations affecting the same positively charged residue in the S4 domain of K(V)7.2 have been found in children affected with benign familial neonatal seizures (R213W mutation) or with neonatal epileptic encephalopathy with severe pharmacoresistant...

The transcription factor NFk B is sequestered in the cytoplasm by the inhibitor proteins of the I k B family. Each member of the I k B exhibits structural and biochemical similarities as well as differences. In an effort to address the functional redundancy of two closely related I k B molecules, I k B a and I k B b , we generated knock-in mice by replacing the I k B a gene with the I k B b gen...

Abstract. In recent work, Zeilberger and the author used a functional equations approach for enumerating permutations with r occurrences of the pattern 12 . . . k. In particular, the approach yielded a polynomial-time enumeration algorithm for any xed r ≥ 0. We extend that approach to patterns of the form 12 . . . (k − 2)(k)(k − 1) by deriving analogous functional equations and using them to de...

The physiological diversity of K+ channels mainly depends on the expression of several genes encoding different alpha-subunits. We have cloned a new K+ channel alpha-subunit (Kv2.3r) that is unable to form functional channels on its own but that has a major regulatory function. Kv2.3r can coassemble selectively with other alpha-subunits to form functional heteromultimeric K+ channels with kinet...

In this study Bis(1,4-dinitro toprop-2-yl) Nitramine, BNA, was attached to boron nitride nano- cages (B12N12). , thermodynamic parameters of BNA with B12N12 have been computed using one of the methods of density functional theory (B3LYP) In the temperature variety 300 to 400 K each 10 degree one times, were calculated. So these materials were geometrically optimized. After that thermodynamic pa...