Acquired von Willebrand’s syndrome (AvWS) is a rare heterogeneous bleeding disorder that could be secondary to many underlying diseases, among which systemic lupus erythematosus (SLE) is a less common cause. We presented an uncommon juvenile-onset SLE with AvWS as the first manifestation, whose autoantibodies were all negative except for low-titer positive antinuclear antibody (ANA). Initial co...

Materials and methods Retrospective analytical study: 22 children, ages between the 4 and 17 years and clinical diagnosis of osteopenia, osteoporosis, calcinosis secondary to rheumatic diseases (Juvenile Idiopatic Arthritis, Systemic Lupus Erythematosus, Juvenile Dermatomiositis, Overlap Syndrome, Panarteritis Nodosa, Familiar Mediterranean Fever). Criteria of inclusion: the patients had to ful...

OBJECTIVE There is wide variation in therapeutic approaches to systemic juvenile idiopathic arthritis (JIA) among North American rheumatologists. Understanding the comparative effectiveness of the diverse therapeutic options available for treatment of systemic JIA can result in better health outcomes. The Childhood Arthritis and Rheumatology Research Alliance (CARRA) developed consensus treatme...

Proliferative lupus nephritis, which is diagnosed by renal biopsy, has significant impact on the treatment choices and long-term prognosis of juvenile SLE (jSLE). Renal biopsies are however not always possible or available, thus leading to an ongoing search for alternative biomarkers. This study aimed develop a clinical predictive machine learning model using routine standard parameters as tool...

Antiphospholipid syndrome is an autoimmune disorder defined as association of vascular thrombosis and/or pregnancy complications with presence of antiphospholipid antibodies (lupus anticoagulant, anticardiolipin and anti-β2 glycoprotein I). It is the most common cause of acquired thrombophilia, and can occur as an independent entity or in relation with other diseases, especially systemic lupus ...

BACKGROUND Central nervous system involvement is common in systemic lupus erythematosus but hydrocephalus, especially in children, is rare. CASE CHARACTERISTICS 6-year-old girl with systemic lupus erythematosus with nephritis, on treatment for four months prior to the presentation with features of raised intracranial pressure. OBSERVATION Computed tomography revealed communicating hydroceph...

INTRODUCTION The association of human immunodeficiency virus and immune dysfunction leading to development of autoimmune markers is well described, but human immunodeficiency virus infection is relatively protective for the development of systemic lupus erythematosus. In contrast, development of systemic lupus erythematosus with hepatitis C and with interferon therapy is well described in a num...

Systemic lupus erythematosus is an autoimmune disease associated with mild valvular regurgitation. However, there have been no detailed reports of infective endocarditis in patients with systemic lupus erythematosus. Here, we describe a case of a 55-year-old woman without any cardiac abnormalities who was diagnosed with lupus nephritis by renal biopsy; she contracted infective endocarditis whil...

paraoxonase-1 (pon1) is a serum hdl-bound enzyme that hydrolyzes a number of aromatic carboxylic acid esters including lipid peroxides, preventing ldl oxidation. systemic lupus erythematosus (sle) patients are at greater risk of oxidative stress, which is associated with abnormal plasma lipid metabolism. in this study, association of pon-55 polymorphism with serum arylesterase (are) activities,...

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