Objective. To identify the mechanism of deformity compensation in patients with post-traumatic kyphosis thoracolumbar junction, based on analysis X-ray results surgical treatment. Material and Methods. The study included data obtained from medical records 69 (47 women, 22 men) operated for painful at levels T12, L1 L2 vertebra. Patients underwent staged interventions a single session. Demograph...

Oesophageal and oesophagogastric junction cancers represent a significant burden to public health. Clinical practice guidelines recommend treatment based on cellular molecular targets from tissue obtained before initiating therapy, including human epidermal growth factor receptor, microsatellite instability, mismatch repair, programmed death-ligand 1 neurotrophic receptor tyrosine kinase gene f...

Chronic itch (CI) is an unpleasant skin sensation accompanied by intense scratching desire that lasts 6 weeks or longer. Despite the high prevalence and negative impact on affected individuals a huge healthcare burden, CI mechanisms are only partially understood, consequently, treatment of remains sub-optimal. The complexity also stems from comorbid existence persistent with other somatic psych...

We present a high-order entropy stable discontinuous Galerkin method for nonlinear conservation laws on both multi-dimensional domains and networks constructed from one-dimensional domains. These methods utilize treatments of interfaces network junctions which retain stability when coupling together discretizations. Numerical experiments verify the proposed schemes, comparisons with fully 2D im...

Introduction. Superficial vein thrombosis is characterized by the formation of thrombi in superficial veins with subocclusion or occlusion venous lumen and its inflammatory reaction, which occurs more often lower extremities. Chronic disease 75–88% cases most important clinically identified factor development thrombosis. The great saphenous affected 60–80% cases. A population-based study found ...

background: gap-junctional intercellular communication (gjic) is implicated in physicological processes and it is vitally important for granulosa cell (gc) differentiation and oocyte growth. we investigated the expression of connexin 43 (cx43), a gap junctional protein, in normal and androstenedione-induced polycystic ovary (pco), the effects of androstenedione on cx43 expression, gjic and prog...

Acquired myasthenia gravis (MG) is an autoimmune disorder of the neuromuscular junction in which patients experience fluctuating skeletal muscle weakness that often affects selected muscle groups preferentially. The target of the autoimmune attack in most cases is the skeletal muscle acetylcholine receptor (AChR), but in others, non-AChR components of the neuromuscular junction, such as the mus...

Vascular permeability is a complex process involving the coordinated regulation of multiple signaling pathways in the endothelial cell. It has long been documented that vascular endothelial growth factor (VEGF) greatly enhances microvascular permeability; however, the molecular mechanisms controlling VEGF-induced permeability remain unknown. Treatment of microvascular endothelial cells with VEG...

Myasthenia gravis (MG) is a chronic autoimmune disorder of the neuromuscular junction characterised by an autoantibody against acetylcholine receptor (AChR-Ab), muscle-specific kinase (MuSK-Ab), lipoprotein-related protein 4 or agrin in postsynaptic membrane at junction. Many patients are resistant to conventional treatment and effective therapies needed. Rituximab (RTX) monoclonal antibody dir...

PURPOSE To evaluate the results of a sequence of 47 laparoscopic Anderson-Hynes pyeloplasties for the treatment of patients with ureteropelvic junction obstruction, independently of the etiology. MATERIALS AND METHODS Twenty male and 27 female patients diagnosed with ureteropelvic junction obstruction were treated by Anderson-Hynes transperitoneal laparoscopic dismembered pyeloplasty from Apr...