OBJECTIVES To describe the acute and late ocular manifestations of toxic epidermal necrosis (TEN), Stevens-Johnson syndrome (SJS), and overlap syndrome and to identify predictors for the development of ocular complications. DESIGN Retrospective cohort study. SETTING A single referral unit in a university hospital. PATIENTS The study included 159 patients (mean [SD] age, 49.9 [19.8] years)...

Background According to recent studies about 1-3% of hypersensitivity reactions are accompanied by skin eruptions. Among these toxic epidermal necrolysis (TEN) and StevensJohnson syndrome (SJS) are rare and the most severe adverse cutaneous drug reactions that predominantly involve the skin and mucous membranes. TEN and SJS affecting approximately 1-4/1,000,000 annually with average reported mo...

Toxic Epidermal Necrolysis (TEN), which is also known as Lyell's syndrome, is a widespread, life-threatening, mucocutaneous disease that is particularly observed secondary to drugtaking and less commonly secondary to infections and immunization. Carbamazepine is associated with benign pruritic rash in 10-15% of the patients, but the life threatening dermatological syndromes like exfoliative der...

BACKGROUND AND AIM The sensitivity and specificity of biomarkers used for predicting peripheral neuropathy of Sjogren's syndrome (SJS) patients remain unsatisfactory. This study aimed to determine the prognostic value of circulating autoantibodies levels in SJS patients with peripheral neuropathy. METHODS Two hundred and fifty serological positive (either anti-Ro or anti-La positive) SJS pati...

Primary Sjögren's Syndrome (pSjS) is an autoimmune disease characterized by sicca (xerophthalmia or xerostomia) symptoms, anti-SS-A (Ro) or anti-SS-B (La) autoantibodies, and lymphocytic infiltrates in the exocrine glands. Disease incidence is estimated to be 0.1-3% of the general population with 0.4-3.1 million individuals in the US with women being nine times more likely to be afflicted with ...

We discuss a method for calculating the Chern-Schwartz-MacPherson (CSM) class of a Schubert variety in the Grassmannian using small resolutions introduced by Zelevinsky. As a consequence, we show how to compute the Chern-Mather class and local Euler obstructions using small resolutions instead of the Nash blowup. The algorithm obtained for CSM classes also allows us to prove new cases of a posi...

The presence of an 'underfill' encapsulant between a micro-electronic device and the underlying substrate is known to substantially improve the thermal fatigue life of flip-chip solder joints, primarily due to load-transfer from the solder to the encapsulant. In this study, a new single joint-shear (SJS) test, which allows the measurement of the strain response of an individual solder ball duri...

It remains unknown how autoimmunity is elicited, although many different mechanisms have been involved. There is a major difficulty in establishing a correlation between triggering events and the actual autoimmune disease because of long prodromal period. In this regard, previous studies reported that sera obtained from the acute stage of SJS/TEN and erythema multiforme contain autoantibodies (...

Proxy advisory …rms have become important players in corporate governance, but the extent of their in‡uence over shareholder votes is debated. We estimate the e¤ect of Institutional Shareholder Services (ISS) recommendations on voting outcomes by exploiting exogenous variation in ISS recommendations generated by a cuto¤ rule in ISS voting guidelines. Using a regression discontinuity design, we ...

Innate immune responses direct the nature and specificity of downstream adaptive responses in autoimmune diseases. One of the strongest markers of innate immunity is the up-regulated expression of interferon (IFN) and IFN-responsive/stimulated genes (IRGs/ISGs). While multiple IRGs are induced during the innate phase of host responses, transcriptome data suggest unique IRG-signatures for differ...