PURPOSE To compare the efficacy of intravitreal bevacizumab (IVB) injection alone or with intravitreal triamcinolone acetonide (IVB/IVT) versus macular photocoagulation (MPC) in bilateral diabetic macular edema (DME). METHODS In this study we revisited data from a subset of subjects previously enrolled in a randomized clinical trial. The original study included 150 eyes randomized to three tr...

While forming the stable IVT mRNA molecule, high concentration and purity plasmid DNA must be obtained to ligase ORF antigen sequence initially copied from with UTR regions. In this study, in stage of creating which is first step COVID-19 vaccine, comparison optimization pDNA containing target were performed as a result isolation alkaline lysis method commercial kit. Plasmid bacteria grown unde...

early in the development of many animals, before transcription begins, any change in the pattern of protein synthesis is attributed to a change in the translational activity or stability of mrna in the egg and early embryo. as a result, translational control is critical for a variety of developmental decisions, including oocyte maturation and initiation of preimplantation development. in this s...

BACKGROUND Up to 25% of stroke patients wake up with a neurological deficit, so called wake-up stroke (WUS). Different imaging approaches that may aid in the selection of patients likely to benefit from reperfusion therapy are currently under investigation. The magnetic resonance imaging (MRI) diffusion weighted imaging - fluid attenuated inversion recovery (DWI-FLAIR) mismatch concept is one p...

OBJECTIVES In this study the authors determined the extent of cellular infiltration and dispersion, and regional vascularization in electrophysiologically (EP) defined zones in post-myocardial infarction (MI) swine ventricle. BACKGROUND The critical isthmus (CI) in post-MI re-entrant ventricular tachycardia (VT) is a target for catheter ablation. In vitro evidence suggests that myofibroblasts...

Because smooth-pursuit eye movements (SPEM) can be executed only in the presence of a moving target, it has been difficult to attribute the neuronal activity observed during the execution of these eye movements to either sensory processing or to motor preparation or execution. Previously, we showed that rhesus monkeys can be trained to perform SPEM directed toward an "imaginary" target defined ...

Introduction: The incidence of postneurosurgical Acinetobacter baumannii ventriculitis/meningitis, primarily due to drug-resistant strains, has increased considerably in recent years. However, limited therapeutic options are available because most antibiotics poorly penetrate the blood-brain barrier, especially pediatric patients. Case Presentation: A five-year-old boy developed ventriculitis e...

OBJECTIVES To describe the frequency and outcome of isolated dysphasia among patients treated with intravenous thrombolysis (IVT). DESIGN Patients registered in the SITS International Stroke Thrombolysis Register (SITS-ISTR). PARTICIPANTS Patients with stroke (N=58,293) treated with IVT between December 2002 and December 2012. SETTING A multinational, prospective, observational monitoring...

Cancer represents a unique cell deregulation disease in patients, therefore it has become clear in recent years that successful treatment will depend on personalized cancer therapy. The immune response against cancer is activated when antigen presenting cells (APC) pick up tumor antigens and present them to CD4 helper cells on MHC II molecules and to cytotoxic T lymphocytes (CTL) on MHC I molec...

Early recanalization of occluded vessels in patients with acute ischemic stroke (AIS) by either intravenous thrombolysis (IVT) or endovascular revascularization has been shown to be associated with improved clinical outcomes and reduced mortality. Since the initial report regarding endovascular treatment (EVT) of AIS in 1983, endovascular techniques have been tremendously improved, advancing fr...