BACKGROUND Numerous epidemiological factors affect the probability of developing breast or ovarian cancer, but no predictor is as determinant as inheriting a mutation in BRCA1 or BRCA2. The concept of the founder effect explains the reduced genetic variability in some populations, according to the theory that new populations can be formed from a reduced number of individuals, so the new populat...

being contemporary with avicenna and rhazes, abu maher shirazi was born in shiraz the 10th century ad. he was known as the rst inuential physician in shiraz in the islamic period and his students, such as haly abbas, called him a great scientist. concerning his signicant impact on medicine in this era, abu maher shirazi is a good candidate for the title “the founder of shiraz medical doctrine”.

a genre of novel was created during abbasid period which is considered the product of this same period. the founder of this genre was a famous writer from hamada, called badi’ al-zamon hamadani. he called it maghama and used it as a means to bring up different social thoughts. after him, hariry used this genre. he exactly followed badi, al-zaman hamadani in creating maghama, discussing its subj...

the round city of ardeshir khwarah, with its concentric layout, can be considered as the first city which established by the founder of the sasanian dynasty as a symbol of the sasanian royal ideology. ardeshir khwarah plays a key role in establishment of sasanian sovereignty and urban planning. however, a little is known about the history of the city. it seems even stranger if we consider the r...

network marketing is a sale distribution method based on profiting plans and the unsound network marketing is its deviated form. in this system, recruiting members suffices and according to the pyramidal plans that the company presents, the recruited person’s capital would be divided among the founder, the individuals on top and near the top of the pyramid, and the sponsor. every person finds a...

Rāmānuja was the founder of Visistādvaita Vedānta School, which is one of the three main schools of Vedānta. According to Rāmānuja, the soul (cit), Brahman, and matter (acit) constitute the three principal ontological realities. Rāmānuja provides some proofs for the existence of the soul, which are mostly based on self-consciousness. The relationship of the soul with the matter, on one hand, an...

The formation of a multi-nucleate myofibre is directed, in Drosophila, by a founder cell. In the embryo, founders are selected by Notch-mediated lateral inhibition, while during adult myogenesis this mechanism of selection does not appear to operate. We show, in the muscles of the adult abdomen, that the Fibroblast growth factor pathway mediates founder cell choice in a novel manner. We suggest...