Porphyrins from 38 cases of different types of porphyria were separated chromatographically and analyzed. Patients with different types of porphyria eliminated porphyrins with different patterns. Simple paper chromatography of the methyl ester of the total porphyrin of a urine sample revealed a chromatographic pattern of the porphyrins characteristic of the type of porphyria. The relative abund...

Transition-metal complexes bearing fluorinated phosphane and thiolate ligands has been an area of study in recent years and the chemical context of the current work is related to the metal-assisted functionalization of fluorinated derivatives. The cis and trans isomers of the square-planar complex bis[(pentafluorophenyl)diphenylphosphane-κP]bis(2,3,5,6-tetrafluorobenzenethiolato-κS)platinum(II)...

Commercially available disopyramide is a racemic mixture of equal parts of dextrorotatory (d-) and levorotatory (l-) optical isomers. We studied the cardiac effects of i.v. administration of each isomer and the racemic mixture (dl-) in six normal males by digitized echocardiography, systolic time intervals and ECG. Both isomers and the racemic mixture produced equally marked dose-dependent nega...

The glutamate analogue, alpha-aminoadipate (alpha AA), was administered in the DL-, D-, and L-forms to chick embryo retinas in vitro. Two-hour incubation of retinas, with each form of alpha AA, resulted in glial swelling of progressive severity as the concentration of the adipate increased. Damage was most severe with the L-isomer, which produced a mixed glial-neuronal lesion that affected inne...

Registry No. HRU~(~-COM~)(CO)~~, 71737-42-3; HRuzOs(pCOMe)(CO)lo( C1 isomer), 116079-24-4; HRuOS2(p-COMe) (CO) (C, isomer), 116079-25-5; HOS~(~-COM~)(CO)~~, 69048-01-7; H3Ru3(p3-COMe)(CO)s, 71562-47-5; H3R~205(p3-COMe)(C0)9, 116079-26-6; H3R~O~2(p3-COMe)(CO)e, 116079-27-7; H3Ru20s(p3-COMe)(C0)7(AsPh3)2, 116079-28-8; H3RuOs2(p3-COMe)(CO)8(AsPh3), 116079-29-9; H3R~20s(~3-COMe)(CO)8(AsPh3), 116079...

The calculation of 15N NMR chemical shifts has been systematically investigated using density functional theory-gauge including/invariant atomic orbitals (DFT-GIAO) approximation at the B3LYP/cc-pVDZ level of theory. General linear regression terms for 15N chemical shift predictions were calculated for nitromethane and liquid ammonia references in DMSO. Both aliphatic and aromatic nitrogens wer...

3'-Azido-3'-deoxythymidine triphosphate (erythro) and its threo isomer were synthesized and investigated for their inhibition of HIV reverse transcriptase from virus isolate U 937/HTLV-III. The erythro isomer was a competitive inhibitor of the reaction directed by (rA)n(dT)12-18 and the Ki value was 0.0022 microM. The threo isomer was at least 100-fold less active. The inhibition was specific f...

We report a joint experimental and theoretical study of CO chemisorption on the golden cages. We find that the Au(17)(-) cage is highly robust and retains its cage structure in Au(17)(CO)(-). On the other hand, the Au(16)(-) cage is transformed to a structure similar to Au(17)(-) upon the adsorption of CO. Au(18)(-) is known to consist of two nearly degenerate structures, i.e., a cage and a pyr...

The Gd(Be,α3n)Dy reaction has been used to study high-spin states in Dy. Pulsed beam conditions were utilised for enhanced isomer sensitivity. An isomer at 2188.1(3) keV with a half-life of 8.3(3) μs has been discovered and assigned K= 8 with a 2-quasineutron configuration. Among eleven γ-ray decay branches, an E2, ∆K= 8 transition to the ground-state band was observed with a reduced hindrance ...

The L isomer of (Y , y-diaminobutyric acid is a major component of the polymixin group of antibiotics (1) and of certain Lathyrus peas (24). Some of the polymixins alsocontain~-a:,y-diaminobutyric acid (1). Although the L acid appears to be neurotoxic in rats, it may not be the neurotoxic agent of human lathyrism (4). Except for distribution and toxicity studies in mice (5, 6) and uptake studie...