نتایج جستجو برای: islets of langerhans

تعداد نتایج: 21165925  

2009
Veronika Leiss Andreas Friebe Franz Hofmann Robert Lukowski

Blood glucose levels are tightly controlled by the two peptide hormones glucagon and insulin. At hyperglycaemia, B-cells in the islets of Langerhans secrete insulin, whereas islet A-cells release glucagon at hypoglycaemia to stimulate e.g. glucose production in the liver. Previously, an important role for nitric oxide (NO) in the development of type-1 diabetes mellitus (insulin dependent diabet...

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Journal: :Biochemical Journal 2004

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Journal: :Cell Death & Differentiation 2005

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Journal: :European Journal of Endocrinology 1998

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2011
Hiroki Saito Masaki Takeuchi Kazuhiro Chida Atsushi Miyajima

Islets of Langerhans are a pancreatic endocrine compartment consisting of insulin-producing β cells together with several other hormone-producing cells. While some insulin-producing cells or immature pancreatic cells have been generated in vitro from ES and iPS cells, islets with proper functions and a three-dimensional (3D) structure have never been successfully produced. To test whether islet...

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Journal: :Diabetologia 1978

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ژورنال: مجله علمی دانشگاه علوم پزشکی بیرجند 2010
شفیعی‌نیک, رضا, منصوری, سید محمدتقی, نقی‌زاده, بهاره, پارسایی, حیدر,

  Background and Aim: Selective PDE3 inhibitors, via cyclic adenosine monophosphate (cAMP) accumulation increase cardiac contraction and augment glucose-induced insulin secretion. In this study, the effects of some synthetic methylquinolinone derivatives (MC1-MC10) on glucose-induced insulin secretion in rats' isolated Langerhans islets model were investigated.   Materials and Methods: After...

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2012
Xiaoning Zhao Yongming G. Tang S. Vincent Wu Charles Wang Ricardo Perfetti Nasif Khoury Dehong Cai Fang He Xiaogang Su Vay Liang W. Go Hongxiang Hui

GLP-1 and its analog have been used in diabetes treatment; however, the direct alteration of gene expression profile in human islets induced by GLP-1 has not been reported. In present study, transcriptional gene expression in the liraglutide-treated human islets was analyzed with 12 human U133A chips including 23000 probe sets. The data compared between liraglutide and control groups showed a s...

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Journal: :The Journal of Experimental Medicine 1996
F S Wong I Visintin L Wen R A Flavell C A Janeway

T cells play an important role in the pathogenesis of diabetes in the nonobese diabetic (NOD) mouse. CD8 cytotoxic T cell lines and clones were generated from the lymphocytic infiltrate in the islets of Langerhans of young (7-wk-old). NOD mice by growing them on (NOD x B6-RIP-B7-1)F1 islets. These cells proliferate specifically to NOD islets and kill NOD islets in vitro. The cells are restricte...

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Journal: :Endocrinologia japonica 1958
H MIYAKE

As Janbon first reported in 1942, some sulfonamide derivatives(S)have an action which lowers blood sugar level, and they are nowadays profited to clinical practice. There are several opinions in regard to the mechanism of the hypoglycemic action of S, such as, increased secretion of insulin or inhibition of the discharge of glucagon, etc. , however, it has not yet been completely understood. It...

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