BACKGROUND The intensely increasing multi-drug resistant microbial infections have encouraged the search for new antimicrobial agents. Hydrazone derivatives are known to exhibit a wide variety of biological activities including anti-microbial. In heterocyclic moiety, imidazo[1,2-a]pyrimidines are the subject of immense interest for their antimicrobial activity and also for their analgesic, anti...

New imidazole derived thiosemicarbazones and hydrazones were prepared by condensation of 4(5)-imidazole carboxaldehyde, 4-(1H-imidazole-1-yl)benzaldehyde and 4-(1H-imidazole-1-yl)acetophenone with a thiosemicarbazide or hydrazide. All compounds were characterized by quantitative elemental analysis, IR and NMR techniques. Eight structures were determined by single crystal X-ray diffraction. The ...

Isatin, also known as 1H-Indole-2, 3-Dione, is an eight-carbon containing endogenous compound found in nature. Erdmann and Laurent synthesized isatin 1840, before it was discovered It versatile distributed tissues body fluids. Isatins have been detected mammalian tissue, their function a biochemical process modulator has the focus of many debates. The moiety shows some important chemical reacti...

a series of indole-based aryl(aroyl)hydrazone analogs of antiplatelet indole-3-carboxaldehyde phenylhydrazone were synthesized by the schiff base formation reaction and their antiplatelet activity was assessed using human platelet rich plasma. the platelet concentrate was obtained using a two-step centrifugation protocol and adp, arachidonic acid and collagen were used as inducers of platelet a...

the synthesis of a novel class of 2-oxoindolin-3-ylidene-(1-arylhydrazinyl)-2-aryl(alkyl)ethylidene derivativesvia a copper-catalyzed tandem reaction of isatin, arylhydrazines, sulfonyl azides and terminal alkynes is described.

Objective: Synthesis and in vitro antimicrobial screening of 2,6-diaminopyridine Schiff bases isatin derivatives.
 Methods: Isatin it’s 5-substituted derivatives (S1-5) were prepared by Sandmeyer method N2-Benzylidenepyridine-2,6-Diamine (M) was obtained the reacting with benzaldehyde. (MS1-5) (M). Resultant compound structures confirmed some analytical techniques’ data. All synthesized sc...

We report full details of a method for 1,3-reductive transposition of α-alkoxy-α,β-unsaturated hydrazones to provide E-alkenes with high 1,4-stereocontrol between the two respective allylic stereocenters. The process couples a chelation-controlled reduction of the hydrazone with an in situ allylic strain controlled retro-ene reaction of an allyl diazene, i.e., an allylic diazene rearrangement. ...