The impact of large-distance contributions on the behaviour of the slopes of the spin-non-flip and of the spin-flip amplitudes is analysed. It is shown that the long tail of the hadron potential in impact parameter space leads to a larger value of the slope for the spin-flip amplitude (without the kinematic factor √ |t|) than for the spin-non-flip amplitude. This effect is taken into account in...

In this paper, we propose a novel Low-Power Dual dynamic node and edge triggered (DDNET) flip flop for Featuring Efficient low power applications. Several art of design techniques have been proposed to eliminate large capacitance in the precharge node of the conventional flip-flop, which drives separately by output pull-up, and pull down transistors. Though the pioneer designs which consumes mu...

Transmembrane lipid translocation (flip-flop) processes are involved in a variety of properties and functions of cell membranes, such as membrane asymmetry and programmed cell death. Yet, flip-flops are one of the least understood dynamical processes in membranes. In this work, we elucidate the molecular mechanism of pore-mediated transmembrane lipid translocation (flip-flop) acquired from exte...

OBJECTIVE Fas ligand (FasL) is a key cytokine which initiates apoptosis when FasL binds to its receptor, Fas. Cardiac myocytes are generally resistant to Fas-induced apoptosis. However, sublethal dose of doxorubicin (Dox) can sensitize cardiac myocytes to Fas-induced apoptosis. We investigated the molecular mechanism by which Dox sensitizes cardiac myocytes to Fas-induced apoptosis. FLICE inhib...

Upon encounter with pathogens, T cells activate several defense mechanisms, one of which is the up-regulation of CD95 ligand (CD95L/FasL) which induces apoptosis in sensitive target cells. Despite expression of the CD95 receptor, however, recently activated T cells are resistant to CD95L, presumably due to an increased expression of antiapoptotic molecules. We show here that, in contrast to nai...

FLIP is an antiapoptotic protein that has been demonstrated to play an important role in inflammation, cancer, and autoimmune diseases. However, it is not known whether increased expression of FLIP (FLICE inhibitory protein) in thyrocytes would alter the development of the thyroid and/or pathogenesis of thyroiditis. To examine the effects of overexpression of this antiapoptotic molecule on the ...

Flip Chip (FC) Technology is gaining an increased level of importance for a variety of applications based on Flip Chip on Board or Flip Chip in Package. The first driving force for the introduction of this Technology was the need to achieve increased speed and performance along with higher I/O count. A breakthrough, however, will be the use of flip chip due to cost reduction. For this aim it is...

Celecoxib is a COX-2 inhibitor that reduces the risk of colon cancer. However, the basis for its cancer chemopreventive activity is not fully understood. In this study, we defined a mechanism of celecoxib action based on degradation of cellular FLICE-inhibitory protein (c-FLIP), a major regulator of the death receptor pathway of apoptosis. c-FLIP protein levels are regulated by ubiquitination a...

Purpose: To analyze the flip-angle dependence and to optimize the statistical precision of a fast three-dimensional T1-mapping technique based on the variable-flip-angle (VFA) method. The proposed single-flip-angle (1FA) approach acquires only a single 3D spoiled gradient-echo data set for each time point of the dynamical series in combination with a longer baseline measurement. Theory and Meth...

Type 2 diabetes mellitus results from an inadequate adaptation of the functional pancreatic beta cell mass in the face of insulin resistance. Changes in the concentration of glucose play an essential role in the regulation of beta cell turnover. In human islets, elevated glucose concentrations impair beta cell proliferation and induce beta cell apoptosis via up-regulation of the Fas receptor. R...