The cytochrome P450 enzyme CYP119, its compound II derivative, and its nitrosyl complex were studied by iron K-edge x-ray absorption spectroscopy. The compound II derivative was prepared by reaction of the resting enzyme with peroxynitrite and had a lifetime of approximately 10 s at 23 degrees C. The CYP119 nitrosyl complex was prepared by reaction of the enzyme with nitrogen monoxide gas or wi...

The iron(IV) nitrido complex PhB(MesIm)3Fe≡N reacts with 1,3-cyclohexadiene to yield the iron(II) pyrrolide complex PhB(MesIm)3Fe(η(5)-C4H4N) in high yield. The mechanism of product formation is proposed to involve sequential [4 + 1] cycloaddition and retro Diels-Alder reactions. Surprisingly, reaction with 1,4-cyclohexadiene yields the same iron-containing product, albeit in substantially lowe...

The title compound, [Fe(NO)(2)(C(18)H(12)F(3)P)(2)]·CHCl(3), belongs to the family of metal dinitrosyl compounds with the general formula Fe(NO)(2)(L)(x), referred to collectively as 'dinitrosyl iron compounds' (DNICs). Herein we report the structure of a dinitrosyl iron diphosphane complex, (Fe(NO)(2)L(2), with L = P(C(6)H(4)-p-F)(3). The structure includes one metal complex mol-ecule and one ...

A series of potentially tetradentate and pentadentate ligands modelled on BPMEN has been prepared and their iron(II) bis(triflate) complexes have been isolated and characterised by spectroscopic and crystallographic techniques (BPMEN = N,N'-bis(pyridylmethyl)ethylenediamine). Changes to the BPMEN ligand have invariably led to complexes with different coordination modes or geometries and with in...

Mycobacteria such as M. tuberculosis represent a significant health concern throughout much of the developing world. In mycobacteria and other pathogenic bacteria, an important virulence factor is the ability of the bacterium to obtain iron from its host. One means of obtaining iron is through the use of siderophores. Brasilibactin A is a membrane bound siderophore produced by Nocardia brasilie...

The syntheses of a novel hydroxyl-functionalized tetradentate NHC/pyridine hybrid ligand and the corresponding Ag(i) and Fe(ii) complexes are presented. Spectroscopic and X-ray diffraction techniques are used for structural investigations and cyclic voltammetry measurements reveal interesting electronic properties. Transmetalation of the trinuclear Ag(i) complex (C1) yields a mononuclear and a ...