Browning is characterized by the formation of beige/brite fat depots in subcutaneous white adipose tissue (sWAT). This study aimed to examine whether the chronic activation of PPARalpha by fenofibrate could induce beige cell depots in the sWAT of diet-induced obese mice. High-fat fed animals presented overweight, insulin resistance and displayed adverse sWAT remodeling. Fenofibrate significantl...

Bu çalışmanın amacı, Anadolu Merinosu koyunlarında irisin hormon yanıtı üzerinde vücut kondüsyon skoru (VKS), laktasyon, gebelik, yaş ve cinsiyetin etkisinin incelenmesidir. Çalışmaya dahil edilen tüm gruplarda yer alan koyunları skorlarına (VKS

Objectives: This study was designed to explore the relationship between serum irisin hormone with VitaminD levels and investigate association of Vitamin D3 concentrations withBMI male healthy individuals in Anbar province.Method: included 84 Iraqi men age range (20-40) year, divided into three groupsdepending on body mass index (BMI). The weight height all participants were taken extract BMI.Th...

Background Irisin is an exercise-linked myokine produced by cleavage of the membrane precursor fibronectin type III domain-containing protein 5 (FNDC5) in skeletal muscle, brain, and other tissues. Recently, irisin has been identified as a key molecule for exercise-induced neuroprotection mouse models Alzheimer’s disease (AD). However, role FNDC5/irisin AD pathology not yet comprehensively expl...

Bone diseases are common among middle-aged and elderly people, harm to activities of daily living (ADL) quality life (QOL) for patients. It is crucial search key regulatory factors associated with the development bone explore potential therapeutic targets diseases. Irisin a novel myokine that has been discovered in recent years. Accumulating evidence indicates irisin beneficial effects treatmen...

Breast cancer (BC) is a malignant neoplasm characterized by abnormal cell growth of breast tissue in an uncontrolled pattern and their ability to infiltrate invade normal locally. Irisin plays important role the occurrence, development, metastasis different tumors. The aim this study evaluate changes serum levels irisin postmenopausal women compared with control group. Serum samples were collec...

Skeletal muscles play an active role in regulating the metabolic homeostasis through their ability for relating to adipose tissue and endocrine hormones. Contraction of the skeletal muscle leads to increased release of several myokines, such as irisin, which is able to interact with the adipose tissue. Physical activity promotes the irisin mechanism by augmenting the peroxisomes (PGC1-α) in the...