BACKGROUND/AIMS According to previous observations, enhanced store-operated Ca2+-entry (SOCE) accomplished by the pore forming ion channel unit Orai1 and its regulator STIM1 contribute to therapy resistance of ovary carcinoma cells. Ca2+ signaling is further shaped by Ca2+ extrusion through K+-independent (NCX) and/or K+-dependent (NCKX) Na+/Ca2+-exchangers. The present study thus explored whet...

Reductions in fluid shear stress produce endothelium-dependent vasoconstriction and promote neointimal hyperplasia, but the intracellular signaling mechanisms involved in these processes are poorly understood. To examine whether decreases in fluid shear stress affect endothelial cytosolic pH, carboxy-seminaphthorhodafluor-1-loaded rat aortic endothelial cells were cultured in glass microcapilla...

Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. The N-terminal, 'membrane-binding' domain of ankyrins contains 24 ANK repeats and mediates most binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin h...

Single staggered is a design development of normal wire and tube heat exchanger that wires are welded with staggered configuration on two sides. Capacity of wire and tube heat exchanger is the ability of the heat exchanger to release heat. The objective of this study is to analyse the effect of wire pitch (pw) on capacity of single staggered wire and tube heat exchanger. The research...

It is well known that the natural cellulose has low ionic exchange properties, due to its characterization by a small number of carboxylic groups. Incorporation different functional groups can promote capacity. In this work, modification orange peel treating with sodium hydroxide and amination, phosphoration sulfonation. The ion exchanger been used increase capacity such materials, developing t...

The vital task of vectorial solute transport is often energised by a plasma membrane, proton-motive V-ATPase. However, its proposed partner, an apical alkali-metal/proton exchanger, has remained elusive. Here, both FlyAtlas microarray data and in situ analyses demonstrate that the bacterial kefB and kefC (members of the CPA2 family) homologues in Drosophila, CG10806 and CG31052, respectively, a...

220-kDa ankyrin-B is required for coordinated assembly of Na/Ca exchanger, Na/K ATPase, and inositol trisphosphate (InsP(3)) receptor at transverse-tubule/sarcoplasmic reticulum sites in cardiomyocytes. A loss-of-function mutation of ankyrin-B identified in an extended kindred causes a dominantly inherited cardiac arrhythmia, initially described as type 4 long QT syndrome. Here we report the id...

Heat exchangers are the critical components of refrigeration and liquefaction processes. Selection of appropriate operational conditions for cryogenic recuperative heat exchanger and expansion valve operating in Joule-Thomson cooling system results in improving the performance and efficiency. In the current study, a straightforward procedure is introduced to design an efficient Joule-Thomson co...

Slc26a2 is a ubiquitously expressed SO4 transporter with high expression levels in cartilage and several epithelia. Mutations in SLC26A2 are associated with diastrophic dysplasia. The mechanism by which Slc26a2 transports SO4 and the ion gradients that mediate SO4 uptake are poorly understood. We report here that Slc26a2 functions as a SO4/2OH, SO4/2Cl and SO4/OH/Cl exchanger, depending on the ...