P-glycoprotein (P-gp) and cytochrome P450 3A4 (CYP3A4) are expressed in the intestine and are associated with drug absorption and metabolism. Pregnane X receptor (PXR) is the key molecule that regulates the expression of P-gp and CYP3A4. Given that PXR activity is regulated by a variety of compounds, it is possible that unknown PXR activators exist among known medicines. Kampo is a Japanese tra...

Sotorasib is effective in KRASG12C mutant non-small cell lung cancer (KRASG12CNSCLC) and under investigation phase III trial. Targeted therapy anti-PD(L)1 sequence/combination associated with adverse event (AE) excess. We sought to describe sotorasib-related AE (SRAE) sequential sotorasib following anti-PD(L)1. Consecutive KRASG12CNSCLC treated outside clinical trial 16 French centers from Janu...

Abstract. Although the northern Indian Ocean (IO) is globally one of most productive regions and receives dissolved iron (DFe) from multiple sources, there no comprehensive understanding how these different sources DFe can impact upper-ocean biogeochemical dynamics. Using an Earth system model with ocean biogeochemistry component, this study shows that atmospheric deposition important source to...

山麦冬属( Li r io p e Lour .)植物系百合科植物 , 中国分布有 8 种(变种) 1 ] ,分别为山麦冬( Li r io p e s p ica ta Lour .) 、湖 北 山 麦 冬 ( Li r io pe sp icata Lour . var . prol i f e ra Y . T . Ma) 、短葶山麦冬 [ Li r io p e musacar li (Decne .) Bailey] 、阔叶山麦冬 ( Li r io p e p lat y phy l la Wang et Tang) 、甘肃山麦冬 [ Li r io p e kansuensi s (Batal .) C . H . Wright] 、禾 叶山麦冬[ Li r io pe g ram ini f olia (L .) Baker]和矮 小山麦冬[ Li r io p e ...