It has now been established that infection with human papillomavirus (HPV) is necessary for the development of most cervical cancers. HPV is not sufficient for the development of cancer. Other exposures or host factors are necessary for cancer to occur. As part of an ongoing, population-based case-control study of invasive cervical cancer, we investigated the role of cigarette smoking, oral con...

Persistent infection with high-risk types of human papillomavirus(HPV) is known to cause cervical cancer; however, additional genetic and epigenetic alterations are required for progression from precancerous disease to invasive cancer. DNA methylation is an early and frequent molecular alteration in cervical carcinogenesis. In this review, we summarize DNA methylation within the HPV genome and ...

Cervical cytology remains the principal screening method to detect pre-invasive and invasive cervical lesions. Management of abnormal cervical cytology depends on the risk of encountering a significant cervical lesion or high-grade cervical disease. These risks may vary in different areas across the country. Thus, determining the rate of significant cervical lesion associated with each type of ...

In Osijek-Baranja County, there was a rise in the number of non-invasive and fall of invasive cervical cancer in the period 2000-2008, but cervical cancer still represents an important public health problem in Osijek-Baranja County. Cervical cancer in 2008 was the ninth female cancer site and represents 3.5% of all malignant diseases in women. In the same year it was also at the ninth place of ...

background: this research was accomplished to evaluate the ihc expression of p16 (ink4a) and ck17 in low grade cervical intraepithelial lesions (lsil), high grade cervical intraepithelial lesions (hsil) and invasive cervical carcinomas and to assess their correlation to hpv (16e6+18e6). methods: the study included (127) formalin-fixed paraffin-embedded cervical biopsies; of which 22 cases were ...

Comments This project has been funded in whole or in part with federal funds from the Summary and Key Points 1. Development of cervical cancer can be tracked as it progresses from cervical intraepithelial neoplasia to cervical carcinoma in situ to invasive cervical cancer. 2. Human papillomavirus infection is central to the development of all cervical cancers. 3. Most cervical cancers are squam...

BACKGROUND Limited data are available describing human papillomavirus (HPV) genotype distributions in cervical cancer in the United States. Such studies are needed to predict how HPV vaccination and HPV-based screening will influence cervical cancer prevention. METHODS We used the New Mexico Surveillance, Epidemiology, and End Results Registry to ascertain cases of in situ (n = 1213) and inva...

Before 1991, Australianwomen underwent opportunistic screening for cervical cancer, usually annually. From 1991, a national, coordinated approach was implemented, the National Cervical Screening Program (NCSP), which included Pap tests (cervical smears) for women aged 18e70 years every 2 years. This approach has resulted in a significant reduction — nearly 50% — in the incidence of cervical can...

Cervical cancer emerges from cervical intraepithelial neoplasia (CIN) induced by high-risk HPV (HR-HPV) infections. However, the vast majority of CIN lesions regresses spontaneously, and only a few lesions persist or progress to invasive carcinoma. On the basis of morphological criteria, it is not possible to differentiate high-grade lesions that will regress or persist from those that inevitab...

BACKGROUND We investigated the effect of Pap smear screening on the incidence of invasive cancer of the cervix in the Western Cape, South Africa where screening is limited. METHODS Data were derived from a case-control study of the association of hormonal contraceptives and invasive cervical cancer. Incident cases (n = 524) of invasive cervical cancer who presented at two tertiary hospitals a...