BACKGROUND Minichromosome maintenance proteins (MCM) are highly expressed in actively replicating cells. The need for biological markers for cervical carcinoma and its precursor lesions is emerging. Our main aim was to determine the immunohistochemical expression of MCM-2 in HIV-positive and -negative dysplastic cervical specimens. METHODS Immunohistochemical analysis of MCM-2 was performed i...

BACKGROUND To assess the association between MTHFR polymorphism and cervical cancer risk, a meta-analysis was performed. METHODS Based on comprehensive searches of the PubMed, Embase, and Web of Science databases, we identified outcome data from all articles estimating the association between MTHFR polymorphism and cervical cancer risk. The pooled odds ratio (OR) with 95% confidence intervals...

1. Treatment of CIN 2. Invasive Carcinoma of the Cervix 1. Clinical presentation 2. Staging 3. Histology 4. Management 1. Stage 1A 2. Stage IB – 2A 3. Stage 2B – 4A 4. Stage 4B 5. Complications 1. Radical Hysterectomy 2. Radiotherapy 6. Minimal Access Surgery 1. Laparoscopic Vaginal Radical Hysterectomy (LVRH) 7. Fertility Sparing Surgery 8. Special Situations 1. Recurrent Cervical Cancer 2. In...

BACKGROUND Visual inspection with acetic acid (VIA) to identify and treat pre-cancerous lesions is effective for cervical cancer prevention. Screening programs also facilitate screening and diagnosis of invasive cancers that must be referred for radiation therapy or chemotherapy. This study compared characteristics of women diagnosed with invasive cervical cancer by a VIA screening program who ...

Cervical cancer is the second leading cause of death from cancer in women worldwide, and recent epidemiological studies have strongly implicated the sexually transmitted human papillomavirus (HPV) as a causative agent. The ability of high-risk HPVs to contribute to malignant progression seems to depend on expression of the viral E6 and E7 oncogenes. The E6 oncoprotein forms a complex with the c...

A micronucleus is an additional small nucleus formed due to chromosomes or chromosomal fragments fail to be incorporated into the nucleus during cell division. In this study, we assessed the utility of micronucleus counting as a screening tool in cervical precancerous lesions in Thinprep cytological test smears under oil immersion. High risk HPV was also detected by hybrid capture-2 in Thinprep...