A 56-year-old man admitted with coronavirus disease 2019 (COVID-19) became severely ill, required ventilator support and intensive care unit management. After weaning, he was found to have quadriparesis. Guillain–Barré syndrome (GBS) suspected administration of high-dose intravenous immunoglobulin (IVIg) considered. However, markedly prolonged compound muscle action potential (CMAP) duration ob...

Miller Fisher syndrome (MFS) is an immune mediated neuropathy commonly triggered by infection. It considered as a variant of Guillain-Barre syndrome. Although bilateral ophthalmoplegia the commonest ocular involvement in MFS, there are reported cases unilateral ophthalmoplegia. MFS has benign course and treatment not required majority unless life threatening complication. We report unusual case...

1. Kumar A, Teuber SS, Gershwin ME. Intravenous immunoglobulin: striving for appropriate use. Int Arch Allergy Immunol. 2006:140:185-98. 2. Fergusson D, Hutton B, Sharma M, Tinmouth A, Wilson K, Cameron DW, Hebert PC. Use of intravenous immunoglobulin for treatment of neurologic conditions: a systematic review. Transfusion (Paris). 2005:45:1640-57. 3. Dalakas MC. Intravenous immune globulin the...

A novel coronavirus (SARS-CoV-2) is responsible for a severe acute respiratory syndrome called disease 2019 (COVID-19). It originated in Wuhan, China, December 2019. Due to its extreme transmissibility with droplets and human contacts, few months, it has become pandemic. Nowadays, no effective therapy available, the scientific community moving find therapeutic choice fight this silent enemy. St...

Objective: High-dose intravenous immunoglobulin (IVIG) decreases the risk for development of coronary arterial lesions (CAL) in Kawasaki disease (KD) while patients resistant to IVIG have higher risk. This study is aimed to investigate an additional therapy affects the risk for CAL in IVIG resistant KD. Design: The information from 11,510 children with KD was collected by the nationwide survey ...

I b a t fi ACKGROUND ome cases of unexplained recurrent spontaneous pregnancy oss have been proposed to arise from an undefined immuological barrier to normal placentation. One proposed treatent, active immunization with allogeneic leukocytes, benfits only 8% to 10% of treated couples, who cannot be elected by means of diagnostic testing (1). Another treatent, passive immunization with intraven...

INTRODUCTION Hemolysis is considered a class effect and a rare adverse event that can occur following therapy with human normal immunoglobulin for intravenous administration [i.e., intravenous immunoglobulin (IVIG)]. Anti-A/B isoagglutinins (also referred to as isohemagglutinins) originating from donor plasma are present in polyvalent immunoglobulin G (IgG) products and are considered a probabl...

to determine the clinical features and treatment outcomes of infant with immune thrombo-cytopenic purpura (itp). retrospective analysis of 96 infant itp patients treated from 1995 to 2005. the data abstracted comprised age, gender, clinical features, and treatment outcomes. the 56 male and 40 female infants had a median age of 3 months. eighty presented with purpura, sixteen with active mucosal...

Intravenous immunoglobin administration is considered very safe. Rare complications like stroke can be very disabling and needs mentioning before offering the therapy to the patient. We report a young Indian patient with no known risk factor of stroke, received intravenous immunoglobulin for treatment of chronic inflammatory demyelinating polyneuropathy, and developed ischemic stroke involving ...

Although the main hematologic findings, such as spherocytosis, polychromasia, anisopoikilocytosis, and reticulocytosis, etc. and Coombs test results were not given, the patient most likely had hemolytic anemia, for which he was given pulse methylprednisolone (MP) three days after intravenous immunoglobulin (IVIG) therapy, which might also cause encephalopathy. However, the hematologic changes w...