Intravaginal rings (IVRs) have emerged as cost effective way to deliver sustained release of drugs as compared to vaginal gels. Hydrophobic polyether polyurethane Intravaginal rings (IVRs) were investigated to deliver antiretroviral (ARV) drug in combination with a HIV reverse transcriptase inhibitor. The ARV used was N-[2-(3,4,5-trumethoxybenzoilthio)benzoyl]-alaninamide (SAMT-10) and the HIV-...

BACKGROUND Supplementation of luteal phase with progesterone is prescribed for women undergoing routine IVF treatment. OBJECTIVE The objective of this study was to compare the efficacy of three types of progesterone on biochemical, clinical and ongoing pregnancy rates and abortion and live birth rates. MATERIALS AND METHODS A prospective randomized study was performed at Royan Institute bet...

OBJECTIVE To evaluate the predictive factors associated with the success of medical abortion by misoprostol monotherapy within 24 hours in the first trimester of pregnancy. METHODS The records of 228 women with miscarriage up to 11 weeks of gestational age who underwent medical abortion by intravaginal misoprostol monotherapy were reviewed. Success of abortion was defined as complete expulsio...

OBJECTIVE To compare severity of negative mood and physical symptoms between women with different progesterone, allopregnanolone, and pregnanolone plasma concentrations during sequential Hormone Replacement Therapy (HRT) with vaginal progesterone suppositories. DESIGN A randomized, placebo-controlled, double-blind, crossover study. METHOD Postmenopausal women (n=36) with climacteric symptom...

Abstract Vulvovaginal candidiasis is a vaginal infection caused by the fungal pathogen Candida albicans that, most commonly, affects women of reproductive age. Its first-line treatment consists in topical applications conventional drug formulations (e.g., creams, gels, tablets) containing imidazole drugs. The involves single or multiple daily and, case recurrences, administration oral antifunga...

A 19-year-old woman was referred to our emergency department for massive vaginal hemorrhage following an attempted clandestine abortion by intravaginal instillation of potassium permanganate crystals. Primigravida, she 7 weeks pregnant and had no particular pathological history. Upon admission, in hemorrhagic shock with blood pressure at 7/3 mmHg tachycardia 152 bpm. Pelvic examination revealed...

Abstract The management of sheep reproduction requires the induction and synchronization estrus cycle ovulation for ewe out-of-season and/or synchronized lambing. These managements are based on insertion an intravaginal device controlled internal drug release (CIDR or sponge) then administration a hormonal injection, such as PMSG, eCG, hCG, GnRH. This study aimed to compare impact CIDR sponges,...

OBJECTIVE To evaluate pelvic floor muscle strength before and after vaginal birth. DESIGN Prospective repeated measures study. SETTING Main district hospital. POPULATION Fifty-five women: 25 primiparae and 20 multiparae following vaginal birth, and 10 women following elective caesarean delivery as a control group. METHODS Pelvic muscle strength was evaluated by palpation, perineometry a...