before and after (b) intravenous injection of 200μL 50mM USRPs or (c) intratracheal administration of 50μL 50 mM USRPs. The presence and position of the tumor in the left lung was confirmed by (d) BLI and (e) histology. The arrows indicate the tumor. The HES-stained histological cut (100X) in (e) corresponds approximately to the image slice in figures (a-c). Intratracheal administration of Gd-b...

Fowl typhoid is a disease of adult chickens and is caused by Salmonella Gallinarum infection via the alimentary tract. The experimental reproduction of fowl typhoid per os (PO) requires artificial conditions to minimize the effect of gastric acid, and several Salmonella serovars have been known to be transmitted via the respiratory route. Therefore, we have hypothesized the existence of a respi...

Although several animal models have been developed to study human pulmonary fibrosis, lack of a perfect model has raised the need for various animal models of pulmonary fibrosis. In this study, we evaluated the pulmonary effect of polyhexamethyleneguanidine phosphate instillation into the lungs of mice to determine the potential of these mice as a murine model of pulmonary fibrosis. Intratrache...

background: some patients with respiratory failure who are in need of mechanical ventilation require sedation to tolerate the inserted endotracheal tube (ett) and other unpleasant stimuli. while a l ight sedation is satisfactory, deep sedation can interfere with the weaning process of patient from mechanical ventilator. nevertheless, so far, the ideal regimen for sedatives and analgesics has no...

We recently proposed that mepenzolate bromide (mepenzolate) would be therapeutically effective against chronic obstructive pulmonary disease (COPD) due to its both anti-inflammatory and bronchodilatory activities. In this study, we examined the benefits and adverse effects associated with different routes of mepenzolate administration in mice. Oral administration of mepenzolate caused not only ...

We describe an extremely rare case of tracheal stenosis caused by unnoticed microscopic fiber-like foreign bodies. A 66-year-old woman complained of dyspnea with inspiratory stridor. Magnifying electroendoscopy and computed tomography revealed stenosis involving the entire circumference of the tracheal lumen. Tracheotomy and biopsy were performed. Histologically, the lesion showed chronic infla...

Acute changes in the surface morphology of hamster tracheobronchial epithelium were examined by scanning electron microscopy following intratracheal administration of ferric oxide or benzo(a)pyrene absorbed to ferric oxide. Multiple instillation of ferric oxide brought about a loss of ciliated cells and broad areas of abnormal, enlarged nonciliated cells with roughened or wrinkled surfaces. The...

Male Sprague-Dawley rats were treated by intratracheal instillation with 1 mg/animal of refractory ceramic fibers. Intratracheal exposure to ceramic fibers led to significant changes of immune response. Results of proliferative activity of spleen lymphocytes showed significantly decreased proliferative activity of T-cells in response to mitogens phytohemagglutinin and concanavalin A in animals ...